PMID- 20805696
OWN - NLM
STAT- MEDLINE
DCOM- 20120109
LR  - 20151119
IS  - 1660-2110 (Electronic)
IS  - 1660-2110 (Linking)
VI  - 117
IP  - 3
DP  - 2011
TI  - Serum biological antioxidant potential predicts the prognosis of hemodialysis 
      patients.
PG  - c230-6
LID - 10.1159/000320201 [doi]
AB  - BACKGROUND: It is well known that oxidative stress is enhanced in patients with 
      end-stage renal disease. However, little is known about the relationship between 
      serum antioxidant capacity and clinical outcome in hemodialysis (HD) patients. 
      METHODS: We examined the relationship between serum biomarkers of oxidative 
      stress and clinical outcomes including all-cause mortality, hospitalization rate 
      and incidence of cardiovascular events in HD patients. As biomarkers of oxidative 
      stress, we measured serum levels of coenzyme Q10 (CoQ10) and biological 
      antioxidant potential (BAP). RESULTS: 108 patients were observed for 30 months as 
      the follow-up periods. The survival group (n = 83) showed significantly higher 
      BAP values compared with those in death groups (n = 25; p < 0.05). When serum BAP 
      levels were divided into two groups by their median value, the group with higher 
      BAP values had a better survival rate than that with lower BAP values on the 
      Kaplan-Meier survival analysis (p = 0.05). Although serum levels of CoQ10 did not 
      show any association with clinical outcomes, lower BAP was selected as an 
      independent risk factor for all-cause mortality as well as the absence of 
      angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers therapy 
      by age-adjusted Cox regression analysis. CONCLUSIONS: This study indicated that 
      BAP could predict the prognosis of HD patients.
CI  - Copyright (c) 2010 S. Karger AG, Basel.
FAU - Ishii, Tomoko
AU  - Ishii T
AD  - Department of Nephrology, Immunology, and Vascular Medicine, Shonan Kamakura 
      General Hospital, Kamakura, Kanagawa, Japan.
FAU - Ohtake, Takayasu
AU  - Ohtake T
FAU - Okamoto, Koji
AU  - Okamoto K
FAU - Mochida, Yasuhiro
AU  - Mochida Y
FAU - Ishioka, Kunihiro
AU  - Ishioka K
FAU - Oka, Machiko
AU  - Oka M
FAU - Maesato, Kyoko
AU  - Maesato K
FAU - Ikee, Ryota
AU  - Ikee R
FAU - Moriya, Hidekazu
AU  - Moriya H
FAU - Hidaka, Sumi
AU  - Hidaka S
FAU - Doi, Kent
AU  - Doi K
FAU - Noiri, Eisei
AU  - Noiri E
FAU - Fujita, Toshiro
AU  - Fujita T
FAU - Kobayashi, Shuzo
AU  - Kobayashi S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20100831
PL  - Switzerland
TA  - Nephron Clin Pract
JT  - Nephron. Clinical practice
JID - 101159763
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Antioxidants/*metabolism
MH  - Biomarkers/blood
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Kidney Diseases/*blood/*diagnosis/mortality
MH  - Lipid Peroxidation/physiology
MH  - Male
MH  - Middle Aged
MH  - Oxidative Stress/*physiology
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Prospective Studies
MH  - *Renal Dialysis/adverse effects/mortality
MH  - Survival Rate/trends
EDAT- 2010/09/02 06:00
MHDA- 2012/01/10 06:00
CRDT- 2010/09/01 06:00
PHST- 2009/12/22 00:00 [received]
PHST- 2010/06/04 00:00 [accepted]
PHST- 2010/09/01 06:00 [entrez]
PHST- 2010/09/02 06:00 [pubmed]
PHST- 2012/01/10 06:00 [medline]
AID - 000320201 [pii]
AID - 10.1159/000320201 [doi]
PST - ppublish
SO  - Nephron Clin Pract. 2011;117(3):c230-6. doi: 10.1159/000320201. Epub 2010 Aug 31.