PMID- 20808265
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20101021
IS  - 1534-6080 (Electronic)
IS  - 0041-1337 (Linking)
VI  - 90
IP  - 8
DP  - 2010 Oct 27
TI  - Impact of HLA compatibility on lung transplant survival and evidence for an HLA 
      restriction phenomenon: a collaborative transplant study report.
PG  - 912-7
LID - 10.1097/TP.0b013e3181f2c981 [doi]
AB  - BACKGROUND: Data concerning the impact of human leukocyte antigen (HLA) 
      compatibility on lung transplant survival rates are limited. METHODS: Using the 
      Collaborative Transplant Study database, 5-year graft outcome according to HLA 
      mismatch was examined in 8020 deceased donor lung transplants performed during 
      1989 to 2009. RESULTS: Graft survival rates showed a stepwise decrease as the 
      combined number of HLA-A+B+DR mismatches increased from one to six (P<0.001). 
      Surprisingly, the 28 grafts with 0 mismatches at all 3 loci had a 1-year survival 
      rate of only 49.7%, significantly lower than for 1, 2, 3, 4, 5, or 6 mismatches 
      (P=0.002, <0.001, <0.001, <0.001, 0.002, and 0.003, respectively). Multivariate 
      regression analysis confirmed that, paradoxically, transplantation of grafts with 
      zero HLA-A+B+DR mismatches was associated with a 19% increase in relative risk of 
      failure. Donor lung preservation for up to 12 hr was not associated with inferior 
      graft survival versus shorter preservation times (P=0.60). CONCLUSIONS: Our data 
      show that a high number of HLA mismatches or zero mismatches impacts unfavorably 
      on lung transplant survival.
FAU - Opelz, Gerhard
AU  - Opelz G
AD  - Department of Transplantation Immunology, University of Heidelberg, Heidelberg, 
      Germany. gerhard.opelz@med.uni-heidelberg.de
FAU - Susal, Caner
AU  - Susal C
FAU - Ruhenstroth, Andrea
AU  - Ruhenstroth A
FAU - Dohler, Bernd
AU  - Dohler B
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DR Antigens)
SB  - IM
CIN - Transplantation. 2010 Oct 27;90(8):823-4. PMID: 20697323
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Female
MH  - Graft Survival/*immunology/physiology
MH  - HLA Antigens/*immunology
MH  - HLA-A Antigens/immunology
MH  - HLA-B Antigens/immunology
MH  - HLA-DR Antigens/immunology
MH  - Histocompatibility Testing/methods
MH  - Humans
MH  - Lung Transplantation/*immunology/mortality/statistics & numerical data
MH  - Male
MH  - Middle Aged
MH  - Survival Rate
MH  - Treatment Outcome
EDAT- 2010/09/03 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/09/03 06:00
PHST- 2010/09/03 06:00 [entrez]
PHST- 2010/09/03 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - 10.1097/TP.0b013e3181f2c981 [doi]
PST - ppublish
SO  - Transplantation. 2010 Oct 27;90(8):912-7. doi: 10.1097/TP.0b013e3181f2c981.