PMID- 20809684
OWN - NLM
STAT- MEDLINE
DCOM- 20110201
LR  - 20220408
IS  - 1557-8593 (Electronic)
IS  - 1520-9156 (Linking)
VI  - 12
IP  - 10
DP  - 2010 Oct
TI  - Association of interleukin-10 polymorphisms with cytokines in type 2 diabetic 
      nephropathy.
PG  - 809-13
LID - 10.1089/dia.2010.0085 [doi]
AB  - OBJECTIVE: Interleukin-10 (IL-10) polymorphic variants are linked with cytokine 
      production and are involved in many chronic inflammatory diseases, including type 
      2 diabetes mellitus (T2DM). We investigated the hypothesis that IL-10 promoter 
      polymorphisms may be associated with cytokine expressions involved in the 
      progression of diabetic nephropathy (DN). STUDY DESIGN: A total of 72 Taiwanese 
      subjects were included in this study; along with a control group, patients had a 
      diagnosis of DN lasting >/=2 years, and patients had a diagnosis of T2DM with 
      normal renal functions lasting >/=5 years. Their IL-10 and tumor necrosis factor-alpha 
      (TNF-alpha) genotyping and association of blood chemistry, plasma IL-10, TNF-alpha, and 
      monocyte chemoattract protein-1 (MCP-1), and urinary MCP-1 were investigated. 
      RESULTS: The IL-10-(-592) genotype exhibited significant association with 
      cytokine expressions in DN: significantly higher TNF-alpha and lower plasma IL-10 
      levels were observed in IL-10-(-592)AA, whereas a higher urine MCP-1 level was 
      found in Taiwanese patients with the IL-10-(-592)CC genotype. CONCLUSIONS: 
      IL-10-(-592) promoter polymorphisms may influence IL-10 and MCP-1 production, 
      which may be an indicator of nephropathy risk in Taiwanese T2DM patients.
FAU - Kung, Wan-Ju
AU  - Kung WJ
AD  - Graduate Institute of Biotechnology, National Pingtung University of Science and 
      Technology, Pingtung, Taiwan.
FAU - Lin, Ching-Chiang
AU  - Lin CC
FAU - Liu, Shyh-Hwa
AU  - Liu SH
FAU - Chaung, Hso-Chi
AU  - Chaung HC
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Diabetes Technol Ther
JT  - Diabetes technology & therapeutics
JID - 100889084
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cytokines)
RN  - 0 (IL10 protein, human)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Chemokine CCL2/blood/urine
MH  - Cytokines/*blood/metabolism
MH  - Diabetes Mellitus, Type 2/*blood/*complications/urine
MH  - Diabetic Nephropathies/*blood/*genetics/metabolism/urine
MH  - Genetic Association Studies
MH  - Humans
MH  - Interleukin-10/blood/*genetics
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Promoter Regions, Genetic
MH  - Taiwan
MH  - Tumor Necrosis Factor-alpha/blood/genetics
EDAT- 2010/09/03 06:00
MHDA- 2011/02/02 06:00
CRDT- 2010/09/03 06:00
PHST- 2010/09/03 06:00 [entrez]
PHST- 2010/09/03 06:00 [pubmed]
PHST- 2011/02/02 06:00 [medline]
AID - 10.1089/dia.2010.0085 [doi]
PST - ppublish
SO  - Diabetes Technol Ther. 2010 Oct;12(10):809-13. doi: 10.1089/dia.2010.0085.