PMID- 20810604
OWN - NLM
STAT- MEDLINE
DCOM- 20110222
LR  - 20240320
IS  - 1538-7755 (Electronic)
IS  - 1055-9965 (Print)
IS  - 1055-9965 (Linking)
VI  - 19
IP  - 11
DP  - 2010 Nov
TI  - Eighteen insulin-like growth factor pathway genes, circulating levels of IGF-I 
      and its binding protein, and risk of prostate and breast cancer.
PG  - 2877-87
LID - 10.1158/1055-9965.EPI-10-0507 [doi]
AB  - BACKGROUND: Circulating levels of insulin-like growth factor I (IGF-I) and its 
      main binding protein, IGF binding protein 3 (IGFBP-3), have been associated with 
      risk of several types of cancer. Heritable factors explain up to 60% of the 
      variation in IGF-I and IGFBP-3 in studies of adult twins. METHODS: We 
      systematically examined common genetic variation in 18 genes in the IGF signaling 
      pathway for associations with circulating levels of IGF-I and IGFBP-3. A total of 
      302 single nucleotide polymorphisms (SNP) were genotyped in >5,500 Caucasian men 
      and 5,500 Caucasian women from the Breast and Prostate Cancer Cohort Consortium. 
      RESULTS: After adjusting for multiple testing, SNPs in the IGF1 and SSTR5 genes 
      were significantly associated with circulating IGF-I (P < 2.1 x 10(-4)); SNPs in 
      the IGFBP3 and IGFALS genes were significantly associated with circulating 
      IGFBP-3. Multi-SNP models explained R(2) = 0.62% of the variation in circulating 
      IGF-I and 3.9% of the variation in circulating IGFBP-3. We saw no significant 
      association between these multi-SNP predictors of circulating IGF-I or IGFBP-3 
      and risk of prostate or breast cancers. CONCLUSION: Common genetic variation in 
      the IGF1 and SSTR5 genes seems to influence circulating IGF-I levels, and 
      variation in IGFBP3 and IGFALS seems to influence circulating IGFBP-3. However, 
      these variants explain only a small percentage of the variation in circulating 
      IGF-I and IGFBP-3 in Caucasian men and women. IMPACT: Further studies are needed 
      to explore contributions from other genetic factors such as rare variants in 
      these genes and variation outside of these genes.
CI  - (c)2010 AACR.
FAU - Gu, Fangyi
AU  - Gu F
AD  - Department of Epidemiology, Harvard School of Public Health, Boston, 
      Massachusetts 02115, USA.
FAU - Schumacher, Fredrick R
AU  - Schumacher FR
FAU - Canzian, Federico
AU  - Canzian F
FAU - Allen, Naomi E
AU  - Allen NE
FAU - Albanes, Demetrius
AU  - Albanes D
FAU - Berg, Christine D
AU  - Berg CD
FAU - Berndt, Sonja I
AU  - Berndt SI
FAU - Boeing, Heiner
AU  - Boeing H
FAU - Bueno-de-Mesquita, H Bas
AU  - Bueno-de-Mesquita HB
FAU - Buring, Julie E
AU  - Buring JE
FAU - Chabbert-Buffet, Nathalie
AU  - Chabbert-Buffet N
FAU - Chanock, Stephen J
AU  - Chanock SJ
FAU - Clavel-Chapelon, Francoise
AU  - Clavel-Chapelon F
FAU - Dumeaux, Vanessa
AU  - Dumeaux V
FAU - Gaziano, J Michael
AU  - Gaziano JM
FAU - Giovannucci, Edward L
AU  - Giovannucci EL
FAU - Haiman, Christopher A
AU  - Haiman CA
FAU - Hankinson, Susan E
AU  - Hankinson SE
FAU - Hayes, Richard B
AU  - Hayes RB
FAU - Henderson, Brian E
AU  - Henderson BE
FAU - Hunter, David J
AU  - Hunter DJ
FAU - Hoover, Robert N
AU  - Hoover RN
FAU - Johansson, Mattias
AU  - Johansson M
FAU - Key, Timothy J
AU  - Key TJ
FAU - Khaw, Kay-Tee
AU  - Khaw KT
FAU - Kolonel, Laurence N
AU  - Kolonel LN
FAU - Lagiou, Pagona
AU  - Lagiou P
FAU - Lee, I-Min
AU  - Lee IM
FAU - LeMarchand, Loic
AU  - LeMarchand L
FAU - Lund, Eiliv
AU  - Lund E
FAU - Ma, Jing
AU  - Ma J
FAU - Onland-Moret, N Charlotte
AU  - Onland-Moret NC
FAU - Overvad, Kim
AU  - Overvad K
FAU - Rodriguez, Laudina
AU  - Rodriguez L
FAU - Sacerdote, Carlotta
AU  - Sacerdote C
FAU - Sanchez, Maria-Jose
AU  - Sanchez MJ
FAU - Stampfer, Meir J
AU  - Stampfer MJ
FAU - Stattin, Par
AU  - Stattin P
FAU - Stram, Daniel O
AU  - Stram DO
FAU - Thomas, Gilles
AU  - Thomas G
FAU - Thun, Michael J
AU  - Thun MJ
FAU - Tjonneland, Anne
AU  - Tjonneland A
FAU - Trichopoulos, Dimitrios
AU  - Trichopoulos D
FAU - Tumino, Rosario
AU  - Tumino R
FAU - Virtamo, Jarmo
AU  - Virtamo J
FAU - Weinstein, Stephanie J
AU  - Weinstein SJ
FAU - Willett, Walter C
AU  - Willett WC
FAU - Yeager, Meredith
AU  - Yeager M
FAU - Zhang, Shumin M
AU  - Zhang SM
FAU - Kaaks, Rudolf
AU  - Kaaks R
FAU - Riboli, Elio
AU  - Riboli E
FAU - Ziegler, Regina G
AU  - Ziegler RG
FAU - Kraft, Peter
AU  - Kraft P
LA  - eng
GR  - G0802851/MRC_/Medical Research Council/United Kingdom
GR  - U01 CA098216/CA/NCI NIH HHS/United States
GR  - G0401527/MRC_/Medical Research Council/United Kingdom
GR  - U01-CA98758/CA/NCI NIH HHS/United States
GR  - U01 CA098758/CA/NCI NIH HHS/United States
GR  - R01 CA097193/CA/NCI NIH HHS/United States
GR  - U01 CA098710/CA/NCI NIH HHS/United States
GR  - U01-CA98233/CA/NCI NIH HHS/United States
GR  - U01-CA98710/CA/NCI NIH HHS/United States
GR  - U01-CA98216/CA/NCI NIH HHS/United States
GR  - U01 CA098233/CA/NCI NIH HHS/United States
GR  - ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
DEP - 20100901
PL  - United States
TA  - Cancer Epidemiol Biomarkers Prev
JT  - Cancer epidemiology, biomarkers & prevention : a publication of the American 
      Association for Cancer Research, cosponsored by the American Society of 
      Preventive Oncology
JID - 9200608
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Carrier Proteins)
RN  - 0 (Glycoproteins)
RN  - 0 (IGFBP3 protein, human)
RN  - 0 (Insulin-Like Growth Factor Binding Protein 3)
RN  - 0 (Insulin-Like Growth Factor Binding Proteins)
RN  - 0 (Receptors, Somatostatin)
RN  - 0 (insulin-like growth factor binding protein, acid labile subunit)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - 8X85ZJG6XJ (somatostatin receptor 5)
SB  - IM
MH  - Aged
MH  - Biomarkers, Tumor/blood/genetics
MH  - Breast Neoplasms/blood/*genetics
MH  - Carrier Proteins/*genetics
MH  - Cohort Studies
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - Glycoproteins/*genetics
MH  - Humans
MH  - Insulin-Like Growth Factor Binding Protein 3
MH  - Insulin-Like Growth Factor Binding Proteins/blood/*genetics
MH  - Insulin-Like Growth Factor I/*genetics/metabolism
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Single Nucleotide
MH  - Prostatic Neoplasms/blood/*genetics
MH  - Receptors, Somatostatin/*genetics
MH  - Risk Factors
MH  - Signal Transduction/genetics
PMC - PMC2989404
MID - NIHMS234242
EDAT- 2010/09/03 06:00
MHDA- 2011/02/23 06:00
PMCR- 2011/11/01
CRDT- 2010/09/03 06:00
PHST- 2010/09/03 06:00 [entrez]
PHST- 2010/09/03 06:00 [pubmed]
PHST- 2011/02/23 06:00 [medline]
PHST- 2011/11/01 00:00 [pmc-release]
AID - 1055-9965.EPI-10-0507 [pii]
AID - 10.1158/1055-9965.EPI-10-0507 [doi]
PST - ppublish
SO  - Cancer Epidemiol Biomarkers Prev. 2010 Nov;19(11):2877-87. doi: 
      10.1158/1055-9965.EPI-10-0507. Epub 2010 Sep 1.