PMID- 20812252
OWN - NLM
STAT- MEDLINE
DCOM- 20110329
LR  - 20151119
IS  - 1099-0496 (Electronic)
IS  - 1099-0496 (Linking)
VI  - 45
IP  - 12
DP  - 2010 Dec
TI  - Airway hyperresponsiveness is associated with total serum immunoglobulin E and 
      sensitization to aeroallergens in Korean adolescents.
PG  - 1220-7
LID - 10.1002/ppul.21312 [doi]
AB  - BACKGROUND: Allergen sensitization and airway hyperresponsiveness (AHR) are the 
      most important characteristics of bronchial asthma and their correlation has been 
      speculated. OBJECTIVE: We attempted to investigate the relationship between 
      sensitization to allergens and AHR to methacholine in Korean high school 
      students. METHODS: A questionnaire survey, methacholine bronchial provocation 
      tests, and skin-prick tests for 16 major allergens were performed on 724 
      students. The mean age of participants was 15.79 +/- 0.40 years old. Serum total 
      immunoglobulin E (IgE) and the fraction of blood eosinophils were measured. 
      RESULTS: AHR (PC(20) < 16 mg/ml) was present in 12.3%. Log total IgE was higher 
      in AHR-positive group than negative group (4.22 +/- 1.55, 3.70 +/- 1.33, P = 0.001). 
      Three hundred eighty-four students (53.0%) were sensitized to more than one 
      allergen, and among them Dermatophagoides pteronyssinus (Der p, 295 students, 
      40.7%) and Dermatophagoides farinae (Der f, 301 students, 41.6%) were most 
      common. The risk of AHR development was high in the group who had sensitization 
      to one allergen (adjusted odds ratio [aOR] = 1.97, 95% confidence interval [CI]: 
      1.13-3.44, P = 0.018) and to more than two allergens (aOR = 2.94, 95% CI: 
      1.32-6.57, P = 0.009). Among the specific allergens, AHR was developed in those 
      who were sensitized to Der f (aOR = 1.73, 95% CI: 1.04-2.86, P = 0.033), dog 
      dander (aOR = 3.97, 95% CI: 1.67-9.51, P = 0.002), and Alternaria (aOR = 3.19, 
      95% CI: 1.24-6.41, P = 0.016). In the groups with high IgE (>300 IU/ml) and high 
      eosinophil fraction (>4%), AHR was more developed than groups who were low in 
      each (aOR = 2.73, 95% CI: 1.15-6.51, P = 0.023; aOR = 10.82, 95% CI: 3.33-35.08, 
      P = 0.001). CONCLUSION: The risk of AHR development was closely linked with 
      allergen sensitization itself, and the number or types of sensitized allergens 
      such as indoor and fungal allergens in Korean young adolescents.
FAU - Kim, Bong-Seong
AU  - Kim BS
AD  - Department of Pediatrics, Childhood Asthma Atopy Center, University of Ulsan 
      College of Medicine, Seoul, Korea.
FAU - Jin, Hyun-Seung
AU  - Jin HS
FAU - Kim, Hyo-Bin
AU  - Kim HB
FAU - Lee, So-Yeon
AU  - Lee SY
FAU - Kim, Ja-Hyung
AU  - Kim JH
FAU - Kwon, Ji-Won
AU  - Kwon JW
FAU - Kim, Byoung-Ju
AU  - Kim BJ
FAU - Yu, Jinho
AU  - Yu J
FAU - Yoo, Sunmi
AU  - Yoo S
FAU - Hong, Soo-Jong
AU  - Hong SJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100901
PL  - United States
TA  - Pediatr Pulmonol
JT  - Pediatric pulmonology
JID - 8510590
RN  - 0 (Allergens)
RN  - 0 (Bronchoconstrictor Agents)
RN  - 0W5ETF9M2K (Methacholine Chloride)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Allergens/*immunology
MH  - Bronchial Hyperreactivity/*diagnosis
MH  - Bronchial Provocation Tests
MH  - Bronchoconstrictor Agents
MH  - Cell Count
MH  - Eosinophils/cytology
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Methacholine Chloride
MH  - Republic of Korea
MH  - Skin Tests
MH  - Surveys and Questionnaires
EDAT- 2010/09/03 06:00
MHDA- 2011/03/30 06:00
CRDT- 2010/09/03 06:00
PHST- 2009/09/03 00:00 [received]
PHST- 2010/05/13 00:00 [revised]
PHST- 2010/06/04 00:00 [accepted]
PHST- 2010/09/03 06:00 [entrez]
PHST- 2010/09/03 06:00 [pubmed]
PHST- 2011/03/30 06:00 [medline]
AID - 10.1002/ppul.21312 [doi]
PST - ppublish
SO  - Pediatr Pulmonol. 2010 Dec;45(12):1220-7. doi: 10.1002/ppul.21312. Epub 2010 Sep 
      1.