PMID- 20812845
OWN - NLM
STAT- MEDLINE
DCOM- 20100924
LR  - 20211020
IS  - 1537-6613 (Electronic)
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 202
IP  - 8
DP  - 2010 Oct 15
TI  - Maternal human leukocyte antigen A*2301 is associated with increased 
      mother-to-child HIV-1 transmission.
PG  - 1273-7
LID - 10.1086/656318 [doi]
AB  - We examined associations between maternal human leukocyte antigen (HLA) and 
      vertical human immunodeficiency virus type 1 (HIV-1) transmission in a perinatal 
      cohort of 277 HIV-infected women in Nairobi. HLA class I genes were amplified by 
      using sequence-specific oligonucleotide probes, and analyses were performed using 
      logistic regression. Maternal HLA-A*2301 was associated with increased 
      transmission risk before and after adjusting for maternal viral load (unadjusted: 
      odds ratio [OR], 3.21; 95% confidence interval [CI], 1.42-7.27; P = .005; Pcorr = 
      0.04; adjusted: OR, 3.07; 95% CI, 1.26-7.51; P =.01; Pcorr is not significant). 
      That maternal HLA-A*2301 was associated with transmission independent of plasma 
      HIV-1 RNA levels suggests that HLA may alter infectivity through mechanisms other 
      than influencing HIV-1 load.
FAU - Mackelprang, Romel D
AU  - Mackelprang RD
AD  - Departments of 1Epidemiology, 2Medicine, 3Global Health, and 4Biostatistics, 
      University of Washington, Seattle, Washington; 5Cancer and Inflammation Program, 
      Laboratory of Experimental Immunology, SAIC-Frederick, Inc, National Cancer 
      Institute at Frederick, Maryland; and 6Department of Paediatrics, University of 
      Nairobi, Kenya.
FAU - Carrington, Mary
AU  - Carrington M
FAU - John-Stewart, Grace
AU  - John-Stewart G
FAU - Lohman-Payne, Barbara
AU  - Lohman-Payne B
FAU - Richardson, Barbra A
AU  - Richardson BA
FAU - Wamalwa, Dalton
AU  - Wamalwa D
FAU - Gao, Xiaojiang
AU  - Gao X
FAU - Majiwa, Maxwel
AU  - Majiwa M
FAU - Mbori-Ngacha, Dorothy
AU  - Mbori-Ngacha D
FAU - Farquhar, Carey
AU  - Farquhar C
LA  - eng
GR  - R01 HD023412-20/HD/NICHD NIH HHS/United States
GR  - D43 TW000007/TW/FIC NIH HHS/United States
GR  - P30 AI027757/AI/NIAID NIH HHS/United States
GR  - N01CO12400/CA/NCI NIH HHS/United States
GR  - K23 HD041879/HD/NICHD NIH HHS/United States
GR  - K01 TW006080/TW/FIC NIH HHS/United States
GR  - R01 HD023412/HD/NICHD NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Cohort Studies
MH  - Female
MH  - HIV Infections/*immunology/*transmission
MH  - *HIV-1
MH  - HLA Antigens/*immunology
MH  - Haplotypes
MH  - Histocompatibility Testing
MH  - Humans
MH  - Infant, Newborn
MH  - *Infectious Disease Transmission, Vertical
MH  - Pregnancy
MH  - Risk Factors
PMC - PMC3404885
MID - NIHMS221341
COIS- Authors do not have a commercial or other association that might pose a conflict 
      of interest.
EDAT- 2010/09/04 06:00
MHDA- 2010/09/25 06:00
PMCR- 2012/07/25
CRDT- 2010/09/04 06:00
PHST- 2010/09/04 06:00 [entrez]
PHST- 2010/09/04 06:00 [pubmed]
PHST- 2010/09/25 06:00 [medline]
PHST- 2012/07/25 00:00 [pmc-release]
AID - 10.1086/656318 [doi]
PST - ppublish
SO  - J Infect Dis. 2010 Oct 15;202(8):1273-7. doi: 10.1086/656318.