PMID- 20813857
OWN - NLM
STAT- MEDLINE
DCOM- 20110218
LR  - 20211020
IS  - 1555-905X (Electronic)
IS  - 1555-9041 (Print)
IS  - 1555-9041 (Linking)
VI  - 5
IP  - 11
DP  - 2010 Nov
TI  - Pathological significance of a panel of urinary biomarkers in patients with 
      drug-induced tubulointerstitial nephritis.
PG  - 1954-9
LID - 10.2215/CJN.02370310 [doi]
AB  - BACKGROUND AND OBJECTIVES: Although a renal biopsy is indispensable for depicting 
      the severity of pathologic lesions in drug-induced tubulointerstitial nephritis 
      (DTIN), it is not acceptable in some cases and cannot be performed serially 
      because of its invasive nature. Therefore, the discovery of noninvasive markers 
      that are closely related to the pathology of DTIN is of great value. DESIGN, 
      SETTING, PARTICIPANTS, & MEASUREMENTS: In this study, the urinary levels of 
      monocyte chemotactic peptide-1 (MCP-1), neutrophil gelatinase-associated 
      lipocalin (NGAL), N-acetyl-beta-d-glucosaminidase, and alpha1-microglobulin were 
      measured in 40 DTIN subjects, and the performances of these parameters for 
      distinguishing different pathologic lesions were compared. RESULTS: Linear 
      correlation and receiver operating characteristic curve analyses showed that 
      urinary MCP-1 levels were able to identify serious interstitial edema and 
      inflammatory infiltration with greater accuracy than the other biomarkers (r = 
      0.501, P < 0.001 and r = 0.768, P < 0.001, respectively), whereas urinary NGAL 
      levels showed the highest correlation coefficient with tubular atrophy (r = 
      0.692, P < 0.001). CONCLUSIONS: These results suggest that these biomarker levels 
      were higher in patients with DTIN than in controls. Urinary MCP-1 levels 
      correlated and were predictive of the gradated severity of acute lesions in DTIN, 
      whereas the roles of NGAL and alpha1-microglobulin in chronic alterations require 
      further study.
FAU - Wu, Yu
AU  - Wu Y
AD  - Renal Division, Department of Medicine, Peking University First Hospital, 
      Beijing, China.
FAU - Yang, Li
AU  - Yang L
FAU - Su, Tao
AU  - Su T
FAU - Wang, Chen
AU  - Wang C
FAU - Liu, Gang
AU  - Liu G
FAU - Li, Xiao-mei
AU  - Li XM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100902
PL  - United States
TA  - Clin J Am Soc Nephrol
JT  - Clinical journal of the American Society of Nephrology : CJASN
JID - 101271570
RN  - 0 (Acute-Phase Proteins)
RN  - 0 (Alpha-Globulins)
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (LCN2 protein, human)
RN  - 0 (Lipocalin-2)
RN  - 0 (Lipocalins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (alpha-1-microglobulin)
RN  - EC 3.2.1.52 (Acetylglucosaminidase)
SB  - IM
MH  - Acetylglucosaminidase/urine
MH  - Acute-Phase Proteins/urine
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alpha-Globulins/urine
MH  - Atrophy
MH  - Biomarkers/urine
MH  - Biopsy
MH  - Case-Control Studies
MH  - Chemokine CCL2/urine
MH  - China
MH  - Female
MH  - Fibrosis
MH  - Humans
MH  - Kidney Tubules/drug effects/*pathology
MH  - Lipocalin-2
MH  - Lipocalins/urine
MH  - Male
MH  - Middle Aged
MH  - Nephritis, Interstitial/chemically induced/*diagnosis/pathology/urine
MH  - Predictive Value of Tests
MH  - Proto-Oncogene Proteins/urine
MH  - ROC Curve
MH  - Severity of Illness Index
MH  - Young Adult
PMC - PMC3001769
EDAT- 2010/09/04 06:00
MHDA- 2011/02/22 06:00
PMCR- 2011/11/01
CRDT- 2010/09/04 06:00
PHST- 2010/09/04 06:00 [entrez]
PHST- 2010/09/04 06:00 [pubmed]
PHST- 2011/02/22 06:00 [medline]
PHST- 2011/11/01 00:00 [pmc-release]
AID - CJN.02370310 [pii]
AID - 02370310 [pii]
AID - 10.2215/CJN.02370310 [doi]
PST - ppublish
SO  - Clin J Am Soc Nephrol. 2010 Nov;5(11):1954-9. doi: 10.2215/CJN.02370310. Epub 
      2010 Sep 2.