PMID- 20814015
OWN - NLM
STAT- MEDLINE
DCOM- 20101220
LR  - 20211020
IS  - 1524-4636 (Electronic)
IS  - 1079-5642 (Print)
IS  - 1079-5642 (Linking)
VI  - 30
IP  - 11
DP  - 2010 Nov
TI  - Cholesterol intake modulates plasma triglyceride levels in 
      glycosylphosphatidylinositol HDL-binding protein 1-deficient mice.
PG  - 2106-13
LID - 10.1161/ATVBAHA.110.214403 [doi]
AB  - OBJECTIVE: To determine whether plasma triglyceride levels in adult 
      Glycosylphosphatidylinositol HDL-binding protein 1 (GPIHBP1)-deficient 
      (Gpihbp1(-/-)) mice would be sensitive to cholesterol intake. METHODS AND 
      RESULTS: Gpihbp1(-/-) mice were fed a Western diet containing 0.15% cholesterol. 
      After 4 to 8 weeks, their plasma triglyceride levels were 113 to 135 mmol/L. When 
      0.005% ezetimibe was added to the diet to block cholesterol absorption, Lpl 
      expression in the liver was reduced significantly, and the plasma triglyceride 
      levels were significantly higher (>170 mmol/L). We also assessed plasma 
      triglyceride levels in Gpihbp1(-/-) mice fed Western diets containing either high 
      (1.3%) or low (0.05%) amounts of cholesterol. The high-cholesterol diet 
      significantly increased Lpl expression in the liver and lowered plasma 
      triglyceride levels. CONCLUSIONS: Treatment of Gpihbp1(-/-) mice with ezetimibe 
      lowers Lpl expression in the liver and increases plasma triglyceride levels. A 
      high-cholesterol diet had the opposite effects. Thus, cholesterol intake 
      modulates plasma triglyceride levels in Gpihbp1(-/-) mice.
FAU - Weinstein, Michael M
AU  - Weinstein MM
AD  - Department of Medicine, David Geffen School of Medicine, University of 
      California, Los Angeles, USA.
FAU - Tu, Yiping
AU  - Tu Y
FAU - Beigneux, Anne P
AU  - Beigneux AP
FAU - Davies, Brandon S J
AU  - Davies BS
FAU - Gin, Peter
AU  - Gin P
FAU - Voss, Constance
AU  - Voss C
FAU - Walzem, Rosemary L
AU  - Walzem RL
FAU - Reue, Karen
AU  - Reue K
FAU - Tontonoz, Peter
AU  - Tontonoz P
FAU - Bensadoun, Andre
AU  - Bensadoun A
FAU - Fong, Loren G
AU  - Fong LG
FAU - Young, Stephen G
AU  - Young SG
LA  - eng
GR  - R01 HL087228/HL/NHLBI NIH HHS/United States
GR  - P01 HL090553/HL/NHLBI NIH HHS/United States
GR  - T32HL69766/HL/NHLBI NIH HHS/United States
GR  - HL094732/HL/NHLBI NIH HHS/United States
GR  - HL087228/HL/NHLBI NIH HHS/United States
GR  - R01 HL094732/HL/NHLBI NIH HHS/United States
GR  - T32 HL069766/HL/NHLBI NIH HHS/United States
GR  - 5P01HL090533/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20100902
PL  - United States
TA  - Arterioscler Thromb Vasc Biol
JT  - Arteriosclerosis, thrombosis, and vascular biology
JID - 9505803
RN  - 0 (Anticholesteremic Agents)
RN  - 0 (Azetidines)
RN  - 0 (Dietary Fats)
RN  - 0 (GPI-HBP1 protein, mouse)
RN  - 0 (Receptors, Lipoprotein)
RN  - 0 (Triglycerides)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - EOR26LQQ24 (Ezetimibe)
SB  - IM
MH  - Animals
MH  - Anticholesteremic Agents/*pharmacology
MH  - Azetidines/*pharmacology
MH  - Cholesterol/*metabolism
MH  - Dietary Fats/*metabolism
MH  - Disease Models, Animal
MH  - Ezetimibe
MH  - Liver/drug effects/metabolism
MH  - Mice
MH  - Receptors, Lipoprotein/*deficiency
MH  - Triglycerides/blood/*metabolism
PMC - PMC2959134
MID - NIHMS237097
EDAT- 2010/09/04 06:00
MHDA- 2010/12/21 06:00
PMCR- 2011/11/01
CRDT- 2010/09/04 06:00
PHST- 2010/09/04 06:00 [entrez]
PHST- 2010/09/04 06:00 [pubmed]
PHST- 2010/12/21 06:00 [medline]
PHST- 2011/11/01 00:00 [pmc-release]
AID - ATVBAHA.110.214403 [pii]
AID - 10.1161/ATVBAHA.110.214403 [doi]
PST - ppublish
SO  - Arterioscler Thromb Vasc Biol. 2010 Nov;30(11):2106-13. doi: 
      10.1161/ATVBAHA.110.214403. Epub 2010 Sep 2.