PMID- 20814625
OWN - NLM
STAT- MEDLINE
DCOM- 20101228
LR  - 20220311
IS  - 1651-2057 (Electronic)
IS  - 0001-5555 (Linking)
VI  - 90
IP  - 5
DP  - 2010 Sep
TI  - Not all intravenous immunoglobulin preparations are equally well tolerated.
PG  - 494-7
LID - 10.2340/00015555-0900 [doi]
AB  - Intravenous immunoglobulin (IVIG) is used for many indications beyond the 
      original substitution in primary antibody deficiency. Whereas many reports 
      mention adverse reactions, no comparative data exist concerning the incidence of 
      side-effects among the different brands of IVIG. We describe here our experience 
      with the use of different IVIG formulations and their tolerability in a select 
      cohort of 40 patients. The IVIG dose ranged from 0.4 to 3 g/kg/day and was given 
      for 1-2742 days. Fourteen patients (35%) experienced mild to severe adverse 
      reactions during or within 48 h of administration of standard IVIG preparation, 
      which did not recur after switching to an alternative preparation. Adverse 
      reactions included headache, fever, chills, nausea, emesis, hypotension and 
      muscle cramps. One patient experienced a severe adverse reaction; he had a 3-day 
      headache following IVIG infusion. Among the 16 patients who received alternative 
      preparation initially, none experienced adverse reactions. In conclusion, this 
      study shows that IVIG preparations are not all equally well tolerated in 
      patients. The data suggest that, perhaps to a comparable extent to the 
      preparation itself, the infusion rate has a major effect. If a reduction in the 
      infusion rate does not minimize side-effects, one should consider switching the 
      IVIG formulation.
FAU - Feldmeyer, Laurence
AU  - Feldmeyer L
AD  - Department of Dermatology, University Hospital Zurich, Switzerland. 
      laurence.feldmeyer@usz.ch
FAU - Benden, Christian
AU  - Benden C
FAU - Haile, Sarah R
AU  - Haile SR
FAU - Boehler, Annette
AU  - Boehler A
FAU - Speich, Rudolf
AU  - Speich R
FAU - French, Lars E
AU  - French LE
FAU - Hofbauer, Gunther F L
AU  - Hofbauer GF
LA  - eng
PT  - Journal Article
PL  - Sweden
TA  - Acta Derm Venereol
JT  - Acta dermato-venereologica
JID - 0370310
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 0 (Immunologic Factors)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Chemistry, Pharmaceutical
MH  - Chills/chemically induced
MH  - Drug Substitution
MH  - Female
MH  - Fever/chemically induced
MH  - Headache/chemically induced
MH  - Humans
MH  - Hypotension/chemically induced
MH  - Immunoglobulins, Intravenous/administration & dosage/*adverse effects
MH  - Immunologic Factors/administration & dosage/*adverse effects
MH  - Infusions, Intravenous
MH  - Male
MH  - Middle Aged
MH  - Muscle Cramp/chemically induced
MH  - Nausea/chemically induced
MH  - Retrospective Studies
MH  - Switzerland
MH  - Time Factors
MH  - Vomiting/chemically induced
MH  - Young Adult
EDAT- 2010/09/04 06:00
MHDA- 2010/12/29 06:00
CRDT- 2010/09/04 06:00
PHST- 2010/09/04 06:00 [entrez]
PHST- 2010/09/04 06:00 [pubmed]
PHST- 2010/12/29 06:00 [medline]
AID - 10.2340/00015555-0900 [doi]
PST - ppublish
SO  - Acta Derm Venereol. 2010 Sep;90(5):494-7. doi: 10.2340/00015555-0900.