PMID- 20817082
OWN - NLM
STAT- MEDLINE
DCOM- 20110511
LR  - 20220408
IS  - 1872-7573 (Electronic)
IS  - 0378-8741 (Linking)
VI  - 132
IP  - 2
DP  - 2010 Nov 11
TI  - Effects of Scutellariae radix and Aloe vera gel extracts on immunoglobulin E and 
      cytokine levels in atopic dermatitis NC/Nga mice.
PG  - 529-32
LID - 10.1016/j.jep.2010.08.049 [doi]
AB  - AIM OF THE STUDY: The present study aimed to investigate the effects of 
      Scutellariae radix (SR) and Aloe vera gel (AV), alone or in combination, on 
      levels of immunoglobulin E (IgE) and inflammatory cytokines in spontaneous atopic 
      dermatitis(AD)-like skin lesions. MATERIALS AND METHODS: After spontaneous 
      AD-like skin lesion was developed by adaptation to conventional conditions, mice 
      were randomly assigned to control, SR (50 mg/kg, p.o.), AV (0.8 mg/kg, p.o.) and 
      SRAV (50 mg of SR and 0.8 mg of AV/kg, p.o.) groups, and were treated for 6 
      weeks. RESULTS: SR and SRAV suppressed IL-5 levels compared with control, but had 
      no effects on IgE levels (P<0.05). AV increased IgE levels, but decreased both 
      IL-5 and IL-10 compared with control (P<0.05). CONCLUSION: These results suggest 
      that SR and AV modulate immunological responses in AD, mainly through influencing 
      IL-5 or IL-10 levels.
CI  - Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Kim, Jinkyung
AU  - Kim J
AD  - Department of Medical Nutrition, Graduate School of East-West Medical Science, 
      Kyung Hee University, Yongin-si, Gyeonggi-do 446-701, Republic of Korea.
FAU - Lee, In seok
AU  - Lee Is
FAU - Park, Soojin
AU  - Park S
FAU - Choue, Ryowon
AU  - Choue R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100915
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Cytokines)
RN  - 0 (Immunologic Factors)
RN  - 0 (Plant Extracts)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - *Aloe
MH  - Animals
MH  - Cytokines/*blood
MH  - Dermatitis, Atopic/*drug therapy/immunology
MH  - Immunoglobulin E/*blood
MH  - Immunologic Factors/*pharmacology
MH  - Male
MH  - Mice
MH  - Phytotherapy
MH  - Plant Extracts/immunology/*pharmacology
MH  - *Scutellaria baicalensis
MH  - Skin/drug effects/immunology/pathology
EDAT- 2010/09/08 06:00
MHDA- 2011/05/12 06:00
CRDT- 2010/09/07 06:00
PHST- 2010/04/13 00:00 [received]
PHST- 2010/08/09 00:00 [revised]
PHST- 2010/08/25 00:00 [accepted]
PHST- 2010/09/07 06:00 [entrez]
PHST- 2010/09/08 06:00 [pubmed]
PHST- 2011/05/12 06:00 [medline]
AID - S0378-8741(10)00613-6 [pii]
AID - 10.1016/j.jep.2010.08.049 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2010 Nov 11;132(2):529-32. doi: 10.1016/j.jep.2010.08.049. Epub 
      2010 Sep 15.