PMID- 20817695
OWN - NLM
STAT- MEDLINE
DCOM- 20110314
LR  - 20151119
IS  - 1879-0844 (Electronic)
IS  - 1388-9842 (Linking)
VI  - 12
IP  - 11
DP  - 2010 Nov
TI  - Prognostic value of endothelial microparticles in patients with heart failure.
PG  - 1223-8
LID - 10.1093/eurjhf/hfq145 [doi]
AB  - AIMS: Heart failure (HF) is associated with endothelial dysfunction. 
      Endothelium-derived microparticles (EMPs) are a novel quantitative plasma marker 
      of endothelial dysfunction. We investigated whether plasma levels of EMPs can 
      predict future cardiovascular events in patients with HF. METHODS AND RESULTS: We 
      enrolled 169 consecutive HF patients (70 ischaemic, 99 non-ischaemic HF) with New 
      York Heart Association (NYHA) class I or more. Plasma CD144-positive EMP levels 
      were measured by flow cytometry in the HF patients and in 31 healthy subjects. We 
      followed the HF patients for mean 30 months. Endpoints were: a composite of 
      cardiovascular events (myocardial infarction, stroke, re-hospitalization for HF, 
      and cardiovascular death) and all-cause mortality. Endothelium-derived 
      microparticle levels increased significantly with NYHA functional class [EMP 
      median (range): healthy, 0.325 (0.164-0.354) x10(6)/mL; NYHA I, 0.484 
      (0.426-0.575); II, 0.646 (0.439-0.795); and III/IV, 0.786 (0.569-1.026), P < 
      0.001]. A total of 33 cardiovascular events and 22 all-cause deaths were 
      registered. Kaplan-Meier analysis demonstrated a significantly higher probability 
      of cardiovascular events in the high-EMP group, but there was only a borderline 
      difference for all-cause mortality (above median; log rank test P = 0.01, P = 
      0.053, respectively). Multivariate Cox regression analysis adjusted for clinical 
      factors, identified high-EMP levels as an independent predictor of future 
      cardiovascular events, but not for all-cause mortality in HF patients [hazard 
      ratio (95% confidence interval): 2.423 (1.034-5.681), P = 0.04 for cardiovascular 
      events; and 2.095 (0.825-5.323), P = 0.12 for all-cause mortality]. CONCLUSION: 
      Endothelial dysfunction assessed by plasma levels of EMPs can independently 
      predict future cardiovascular events in patients with HF. Endothelium-derived 
      microparticles are a potentially useful biomarker of endothelial dysfunction in 
      HF risk stratification.
FAU - Nozaki, Toshimitsu
AU  - Nozaki T
AD  - Department of Cardiovascular Medicine, Faculty of Life Sciences, Kumamoto 
      University, 1-1-1 Honjo, Kumamoto City, Japan.
FAU - Sugiyama, Seigo
AU  - Sugiyama S
FAU - Sugamura, Koichi
AU  - Sugamura K
FAU - Ohba, Keisuke
AU  - Ohba K
FAU - Matsuzawa, Yasushi
AU  - Matsuzawa Y
FAU - Konishi, Masaaki
AU  - Konishi M
FAU - Matsubara, Junichi
AU  - Matsubara J
FAU - Akiyama, Eiichi
AU  - Akiyama E
FAU - Sumida, Hitoshi
AU  - Sumida H
FAU - Matsui, Kunihiko
AU  - Matsui K
FAU - Jinnouchi, Hideaki
AU  - Jinnouchi H
FAU - Ogawa, Hisao
AU  - Ogawa H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100903
PL  - England
TA  - Eur J Heart Fail
JT  - European journal of heart failure
JID - 100887595
RN  - 0 (Antigens, CD)
RN  - 0 (Biomarkers)
RN  - 0 (Cadherins)
RN  - 0 (cadherin 5)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Aged
MH  - Antigens, CD/*blood
MH  - Biomarkers/blood
MH  - Cadherins/*blood
MH  - Cell-Derived Microparticles/*metabolism
MH  - Endothelium, Vascular/*cytology/*physiopathology
MH  - Female
MH  - Glomerular Filtration Rate
MH  - Heart Failure/*blood/mortality
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/blood
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Risk Assessment
EDAT- 2010/09/08 06:00
MHDA- 2011/03/15 06:00
CRDT- 2010/09/07 06:00
PHST- 2010/09/07 06:00 [entrez]
PHST- 2010/09/08 06:00 [pubmed]
PHST- 2011/03/15 06:00 [medline]
AID - hfq145 [pii]
AID - 10.1093/eurjhf/hfq145 [doi]
PST - ppublish
SO  - Eur J Heart Fail. 2010 Nov;12(11):1223-8. doi: 10.1093/eurjhf/hfq145. Epub 2010 
      Sep 3.