PMID- 20818672
OWN - NLM
STAT- MEDLINE
DCOM- 20110222
LR  - 20101026
IS  - 1531-8257 (Electronic)
IS  - 0885-3185 (Linking)
VI  - 25
IP  - 14
DP  - 2010 Oct 30
TI  - Cerebellar dysfunction in progressive supranuclear palsy: a transcranial magnetic 
      stimulation study.
PG  - 2413-9
LID - 10.1002/mds.23298 [doi]
AB  - Progressive supranuclear palsy (PSP) rarely shows cerebellar signs and symptoms 
      even though the cerebellar dentate nuclei are involved pathologically. This study 
      evaluates cerebellar function using transcranial magnetic stimulation (TMS) to 
      determine whether subclinical cerebellar involvement is present in PSP patients. 
      We studied 11 patients with PSP, 11 patients with Parkinson's disease (PD), and 
      10 age-matched controls. Patients were examined with their usual medications and 
      in their relative on state. Motor evoked potentials (MEPs) were recorded from the 
      hand muscle. Cerebellar function was evaluated using suppressive effects of TMS 
      over the cerebellum on MEPs elicited by TMS over the contralateral motor cortex, 
      which we call cerebellar inhibition (CBI). Interstimulus intervals (ISIs) of 4 to 
      8 ms were used, and the time course of CBI was analyzed. The CBI was reduced in 
      PSP patients. By contrast, the CBI was normal in PD patients in their on state. 
      Although the CBI in their off state should be examined in future studies, the 
      results described herein suggest that Purkinje cells or the 
      dentato-thalamo-cortical pathway assessed by CBI is involved in PSP. Our results 
      are compatible with the pathological findings showing severe dentate nucleus 
      degeneration in PSP patients.
FAU - Shirota, Yuichiro
AU  - Shirota Y
AD  - Department of Neurology, Division of Neuroscience, Graduate School of Medicine, 
      University of Tokyo, Tokyo, Japan. yshirota-tky@umin.ac.jp
FAU - Hamada, Masashi
AU  - Hamada M
FAU - Hanajima, Ritsuko
AU  - Hanajima R
FAU - Terao, Yasuo
AU  - Terao Y
FAU - Matsumoto, Hideyuki
AU  - Matsumoto H
FAU - Ohminami, Shinya
AU  - Ohminami S
FAU - Tsuji, Shoji
AU  - Tsuji S
FAU - Ugawa, Yoshikazu
AU  - Ugawa Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Mov Disord
JT  - Movement disorders : official journal of the Movement Disorder Society
JID - 8610688
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Analysis of Variance
MH  - Case-Control Studies
MH  - Cerebellar Diseases/*etiology
MH  - Electroencephalography/methods
MH  - Electromyography/methods
MH  - Evoked Potentials, Motor/physiology
MH  - Female
MH  - Hand/innervation
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Muscle, Skeletal/physiopathology
MH  - Reaction Time/physiology
MH  - Severity of Illness Index
MH  - Statistics as Topic
MH  - Statistics, Nonparametric
MH  - Supranuclear Palsy, Progressive/*complications
MH  - Time Factors
MH  - *Transcranial Magnetic Stimulation
EDAT- 2010/09/08 06:00
MHDA- 2011/02/23 06:00
CRDT- 2010/09/07 06:00
PHST- 2010/09/07 06:00 [entrez]
PHST- 2010/09/08 06:00 [pubmed]
PHST- 2011/02/23 06:00 [medline]
AID - 10.1002/mds.23298 [doi]
PST - ppublish
SO  - Mov Disord. 2010 Oct 30;25(14):2413-9. doi: 10.1002/mds.23298.