PMID- 20819217
OWN - NLM
STAT- MEDLINE
DCOM- 20101202
LR  - 20221207
IS  - 1476-069X (Electronic)
IS  - 1476-069X (Linking)
VI  - 9
DP  - 2010 Sep 6
TI  - Association of maternal serum concentrations of 2,2', 4,4'5,5'-hexachlorobiphenyl 
      (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE) levels 
      with birth weight, gestational age and preterm births in Inuit and European 
      populations.
PG  - 56
LID - 10.1186/1476-069X-9-56 [doi]
AB  - BACKGROUND: Epidemiological studies on the association between maternal exposure 
      to persistent organic pollutants (POPs) and fetal growth alteration report 
      inconsistent findings which weights in favor of additional studies. METHODS: 
      Blood samples were collected from interviewed pregnant women in Greenland (572), 
      Kharkiv (611) and Warsaw (258) and were analyzed for CB-153 and p,p'-DDE by gas 
      chromatography-mass spectrometry. Data on birth weight, gestational age and 
      preterm birth were obtained for 1322 singleton live births. We examined the 
      association between natural log-transformed serum POPs concentration and birth 
      weight and gestational age using multiple linear regression and the association 
      with prematurity using logistic regression controlling for potential confounding 
      factors. RESULTS: The median serum concentrations of CB-153 and p,p'-DDE were for 
      Inuit mothers 105.6 and 298.9, for Kharkiv mothers 27.0 and 645.4 and for Warsaw 
      mothers 10.7 and 365.2 ng/g lipids, respectively. Increase in CB-153 
      concentration by one unit on the log scale in Inuit mothers serum was associated 
      with significant decrease in infant birth weight of -59 g and gestational age by 
      -0.2 week. Decreases observed in the cohorts in Kharkiv (-10 g and -0.1 week) and 
      in Warsaw (-49 g and -0.2 week) were not statistically significant. Increase in 
      p,p'-DDE concentration by one unit on the log scale was associated with a 
      statistically significant decrease in infant birth weight of -39.4 g and -104.3 g 
      and shortening of gestational age of -0.2 week and -0.6 week in the Inuit and 
      Warsaw cohorts, respectively. In the Kharkiv cohort decrease in birth weight 
      (-30.5 g) was not significant, however a shortening of gestational age of -0.2 
      week per increase in p,p'-DDE concentration by one unit on the log scale was of 
      the borderline significance. There was no significant association between CB-153 
      and p,p'-DDE concentrations and risk of preterm birth however, in all cohorts the 
      odds ratio was above 1. CONCLUSIONS: In utero exposure to POPs may reduce birth 
      weight and gestational age of newborns however, new insights as to why results 
      vary across studies were not apparent.
FAU - Wojtyniak, Bogdan J
AU  - Wojtyniak BJ
AD  - Department-Centre of Monitoring and Analyses of Population Health, National 
      Institute of Public Health-National Institute of Hygiene, Warsaw, Poland. 
      bogdan@pzh.gov.pl
FAU - Rabczenko, Daniel
AU  - Rabczenko D
FAU - Jonsson, Bo A G
AU  - Jonsson BA
FAU - Zvezday, Valentyna
AU  - Zvezday V
FAU - Pedersen, Henning S
AU  - Pedersen HS
FAU - Rylander, Lars
AU  - Rylander L
FAU - Toft, Gunnar
AU  - Toft G
FAU - Ludwicki, Jan K
AU  - Ludwicki JK
FAU - Goralczyk, Katarzyna
AU  - Goralczyk K
FAU - Lesovaya, Anna
AU  - Lesovaya A
FAU - Hagmar, Lars
AU  - Hagmar L
FAU - Bonde, Jens Peter
AU  - Bonde JP
CN  - INUENDO research group
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20100906
PL  - England
TA  - Environ Health
JT  - Environmental health : a global access science source
JID - 101147645
RN  - 0 (Biomarkers)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
SB  - IM
MH  - Biomarkers/blood
MH  - Birth Weight/*drug effects
MH  - Cohort Studies
MH  - Dichlorodiphenyl Dichloroethylene/*blood/toxicity
MH  - Environmental Pollutants/*blood/toxicity
MH  - Female
MH  - Gestational Age
MH  - Greenland
MH  - Humans
MH  - Hydrocarbons, Chlorinated/*blood/toxicity
MH  - Infant, Newborn
MH  - Infant, Premature/growth & development
MH  - Inuit
MH  - Male
MH  - Maternal Exposure/*adverse effects
MH  - Poland
MH  - Pregnancy
MH  - Pregnant Women
MH  - Prenatal Exposure Delayed Effects
MH  - Ukraine
MH  - White People
PMC - PMC2944244
EDAT- 2010/09/08 06:00
MHDA- 2010/12/14 06:00
PMCR- 2010/09/06
CRDT- 2010/09/08 06:00
PHST- 2009/11/25 00:00 [received]
PHST- 2010/09/06 00:00 [accepted]
PHST- 2010/09/08 06:00 [entrez]
PHST- 2010/09/08 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PHST- 2010/09/06 00:00 [pmc-release]
AID - 1476-069X-9-56 [pii]
AID - 10.1186/1476-069X-9-56 [doi]
PST - epublish
SO  - Environ Health. 2010 Sep 6;9:56. doi: 10.1186/1476-069X-9-56.