PMID- 20819536
OWN - NLM
STAT- MEDLINE
DCOM- 20110203
LR  - 20151119
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Linking)
VI  - 123
IP  - 15
DP  - 2010 Aug 5
TI  - Long-term prognostic value of analysis of sympathetic drive by myocardial 
      123I-metaiodobenzylganidine scintigraphy in chronic heart failure.
PG  - 2023-7
AB  - BACKGROUND: The over increase of sympathetic drive in chronic heart failure (CHF) 
      is with main responsibility for the deterioration and mortality of the disease. 
      Myocardial (123)I-metaiodobenzylganidine (MIBG) scintigraphy is a non-invasive 
      convenient method to assess sympathetic dysfunction in patients with CHF. The aim 
      of the study was to detect if sympathetic antidrive analysed through myocardial 
      MIBG scintigraphy plays a crucial role in long-term prognosis in CHF. METHODS: 
      Sixty-four enrolled patients underwent myocardial MIBG scintigraphy, and their 
      plasma concentration of brain natriuretic peptide (BNP), myocardial contractile 
      reserve (MCR), rest left ventricular ejection fraction (rest LVEF) and New York 
      Heart Association (NYHA) function class were assessed. They were separated into 
      groups according to median of above parameters. Endpoint was cardiac death and it 
      was recorded in each group during average 54 months' follow-up. RESULTS: At the 
      end of follow-up, group with lower ratio of heart/mediastinum (H/M) had more 
      death events (P = 0.001), and its BNP level was higher and MCR level was lower (P 
      = 0.003 and 0.001, respectively); but its rest LVEF and NYHA function class were 
      not significantly different. H/M, MCR and BNP correlated closely with death (P = 
      0.000, 0.000 and 0.001, respectively). Among the three indicators the death risk 
      ratio (RR) of H/M was 4.66, more than MCR and BNP (1.88 and 2.56, respectively). 
      However, rest LVEF and NYHA function class did not correlate with death (P = 
      0.652 and 0.384, respectively). The group with lower H/M and MCR, higher BNP had 
      much more death than that with higher H/M and MCR, lower BNP, the RR being 12.8. 
      CONCLUSIONS: Myocardial MIBG scintigraphy is a long-term prognostic marker in 
      CHF. BNP, MCR are also excellent predictors of long-term prognosis in CHF, but 
      not stronger than myocardial MIBG scintigraphy. If the three indicators were 
      joined together, the prediction would become most powerful. Rest LVEF and NYHA 
      have no significance in long-term prediction of CHF.
FAU - Cao, Ya-min
AU  - Cao YM
AD  - Institute of Geriatric Cardiology, General Hospital of Chinese People's 
      Liberation Army, Beijing 100853, China. yaminc@sina.com
FAU - Patrick, Jourdain
AU  - Patrick J
FAU - Francois, Funck
AU  - Francois F
LA  - eng
PT  - Journal Article
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
RN  - 0 (Natriuretic Peptides)
RN  - 35MRW7B4AD (3-Iodobenzylguanidine)
RN  - 9087-70-1 (Aprotinin)
RN  - 9G34HU7RV0 (Edetic Acid)
SB  - IM
CIN - Chin Med J (Engl). 2011 Apr;124(7):1118. PMID: 21542980
MH  - *3-Iodobenzylguanidine
MH  - Adult
MH  - Aged
MH  - Aprotinin/chemistry
MH  - Brain/metabolism
MH  - Echocardiography
MH  - Edetic Acid/chemistry
MH  - Female
MH  - Heart Failure/metabolism/*pathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Perfusion Imaging/*methods
MH  - Natriuretic Peptides/metabolism
MH  - Prognosis
MH  - Prospective Studies
EDAT- 2010/09/08 06:00
MHDA- 2011/02/04 06:00
CRDT- 2010/09/08 06:00
PHST- 2010/09/08 06:00 [entrez]
PHST- 2010/09/08 06:00 [pubmed]
PHST- 2011/02/04 06:00 [medline]
PST - ppublish
SO  - Chin Med J (Engl). 2010 Aug 5;123(15):2023-7.