PMID- 20820131
OWN - NLM
STAT- MEDLINE
DCOM- 20110926
LR  - 20220408
IS  - 1720-8386 (Electronic)
IS  - 0391-4097 (Linking)
VI  - 34
IP  - 3
DP  - 2011 Mar
TI  - Association of increased parathyroid hormone with neuroendocrine activation and 
      endothelial dysfunction in elderly men with heart failure.
PG  - e78-85
AB  - High PTH levels have been reported in patients with chronic heart failure (CHF). 
      Similarly, its levels increase with aging and are related to impaired survival in 
      elderly adults. However, its relationship with neuroendocrine activation and 
      endothelial dysfunction in CHF has not been previously studied. Seventy-three CHF 
      males with New York Heart Association (NYHA) classes II and III and 20 control 
      subjects aged >/= 55 yr were recruited. PTH, 25-hydroxyvitamin D [25(OH)D], 
      N-terminal pro-brain natriuretic peptide (NT-pro-BNP), adiponectin, and 
      osteoprotegerin were measured. Endothelial function (brachial flow mediated 
      dilation), echocardiography, physical performance, and quality of life were 
      assessed, as well. CHF patients had markedly increased serum PTH (77 +/- 33 vs 40 +/- 
      11 pg/ml, p<0.0001), NT-pro-BNP [1809 (2742) vs 67 (74) pg/ml, p<0.0001], 
      adiponectin (17 +/- 9 vs 10 +/- 2 mug/ml, p<0.0001), osteoprotegerin, whereas 25(OH)D 
      levels were decreased compared to controls. Increased PTH is positively 
      correlated with NTpro- BNP (r=0.399, p<0.0001), adiponectin (r=0.398, p<0.0001), 
      and osteoprotegerin, whereas negatively with 25(OH)D in CHF patients. 
      Additionally, increased serum PTH was associated with endothelial dysfunction, 
      echocardiographic variables of heart failure progression, impaired physical 
      performance, and deteriorated quality of life. In a multivariate linear 
      regression analysis, increased serum PTH was independently associated with 
      neuroendocrine activation (NT-pro-BNP, adiponectin) and endothelial dysfunction 
      in elderly CHF men (R2=0.455). Additionally, demonstrated relations with other 
      well-established variables of heart failure severity suggest the potential role 
      of serum PTH in the pathogenesis and non-invasive monitoring of heart failure 
      progression. Future studies are needed to evaluate the predictive value of serum 
      PTH for clinical outcomes as well as beneficial potential of PTH suppression in 
      CHF patients.
FAU - Loncar, G
AU  - Loncar G
AD  - Cardiology Department, Clinical Medical Center Zvezdara, Belgrade, Serbia.
FAU - Bozic, B
AU  - Bozic B
FAU - Dimkovic, S
AU  - Dimkovic S
FAU - Prodanovic, N
AU  - Prodanovic N
FAU - Radojicic, Z
AU  - Radojicic Z
FAU - Cvorovic, V
AU  - Cvorovic V
FAU - Putnikovic, B
AU  - Putnikovic B
FAU - Popovic, V
AU  - Popovic V
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100902
PL  - Italy
TA  - J Endocrinol Invest
JT  - Journal of endocrinological investigation
JID - 7806594
RN  - 0 (Adiponectin)
RN  - 0 (Osteoprotegerin)
RN  - 0 (Parathyroid Hormone)
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 1406-16-2 (Vitamin D)
SB  - IM
MH  - Adiponectin/blood
MH  - Aged
MH  - Chronic Disease
MH  - Endothelium, Vascular/*physiopathology
MH  - Heart Failure/*blood/*physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/blood
MH  - Neurosecretory Systems/*physiology
MH  - Osteoprotegerin/blood
MH  - Parathyroid Hormone/*blood
MH  - Peptide Fragments/blood
MH  - ROC Curve
MH  - Vascular Diseases/blood/physiopathology
MH  - Vitamin D/blood
EDAT- 2010/09/08 06:00
MHDA- 2011/09/29 06:00
CRDT- 2010/09/08 06:00
PHST- 2010/09/08 06:00 [entrez]
PHST- 2010/09/08 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - 7256 [pii]
AID - 10.1007/BF03347080 [doi]
PST - ppublish
SO  - J Endocrinol Invest. 2011 Mar;34(3):e78-85. doi: 10.1007/BF03347080. Epub 2010 
      Sep 2.