PMID- 20820170
OWN - NLM
STAT- MEDLINE
DCOM- 20110810
LR  - 20181201
IS  - 1476-5497 (Electronic)
IS  - 0307-0565 (Linking)
VI  - 35
IP  - 5
DP  - 2011 May
TI  - Inverse associations between long-term weight change and serum concentrations of 
      persistent organic pollutants.
PG  - 744-7
LID - 10.1038/ijo.2010.188 [doi]
AB  - There is emerging evidence that persistent organic pollutants (POPs) can increase 
      the risk of various chronic diseases. As POPs mainly bioaccumulate in adipose 
      tissue, weight change can affect serum concentrations of POPs. However, there are 
      few population-based studies on effects of long-term weight change on serum 
      concentrations of POPs. We examined associations between self-reported weight 
      change over 1 year and 10 years and serum concentrations of seven POPs in 1099 
      adults aged >/= 40. Serum concentrations of most POPs were higher in those with 
      long-term weight loss, whereas they were lower in those with long-term weight 
      gain. Adjusted correlation coefficients of each POP with weight change for 10 
      years were -0.23 (P < 0.01) for trans-nonachlor, -0.16 (P < 0.01) for 
      p,p'-dichlorodiphenyldichloroethylene, and -0.21 (P < 0.01) for 
      beta-hexachlorocyclohexane, -0.16 (P < 0.01) for PCB169, -0.20 (P < 0.01) for PCB180 
      and -0.17 (P < 0.01) for 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin. Weight change 
      for 1 year showed similar but weaker associations, compared with those of 
      long-term weight changes. Although both beneficial health effects after weight 
      loss and harmful health effects after weight gain are generally expected, changes 
      in serum concentrations of POPs in relation to weight change may act on health in 
      directions opposite to what we expect with weight change.
FAU - Lim, J S
AU  - Lim JS
AD  - Department of Preventive Medicine, School of Medicine, Kyungpook National 
      University, Daegu, Korea.
FAU - Son, H-K
AU  - Son HK
FAU - Park, S-K
AU  - Park SK
FAU - Jacobs, D R Jr
AU  - Jacobs DR Jr
FAU - Lee, D-H
AU  - Lee DH
LA  - eng
PT  - Journal Article
DEP - 20100907
PL  - England
TA  - Int J Obes (Lond)
JT  - International journal of obesity (2005)
JID - 101256108
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Polychlorinated Dibenzodioxins)
RN  - 0 (Xenobiotics)
RN  - 3734-49-4 (nonachlor)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - 59NEE7PCAB (Hexachlorocyclohexane)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - MM6333103R (1,2,3,4,6,7,8-heptachlorodibenzodioxin)
RN  - T2P1WH546D (3,4,5,3',4',5'-hexachlorobiphenyl)
RN  - YM80ODM9PD (beta-hexachlorocyclohexane)
SB  - IM
MH  - Dichlorodiphenyl Dichloroethylene/blood
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Hexachlorocyclohexane/blood
MH  - Humans
MH  - Hydrocarbons, Chlorinated/blood
MH  - Male
MH  - Polychlorinated Biphenyls/blood
MH  - Polychlorinated Dibenzodioxins/analogs & derivatives/blood
MH  - Risk Factors
MH  - *Weight Gain
MH  - *Weight Loss
MH  - Xenobiotics/*blood
EDAT- 2010/09/08 06:00
MHDA- 2011/08/11 06:00
CRDT- 2010/09/08 06:00
PHST- 2010/09/08 06:00 [entrez]
PHST- 2010/09/08 06:00 [pubmed]
PHST- 2011/08/11 06:00 [medline]
AID - ijo2010188 [pii]
AID - 10.1038/ijo.2010.188 [doi]
PST - ppublish
SO  - Int J Obes (Lond). 2011 May;35(5):744-7. doi: 10.1038/ijo.2010.188. Epub 2010 Sep 
      7.