PMID- 20820626
OWN - NLM
STAT- MEDLINE
DCOM- 20110124
LR  - 20171116
IS  - 1464-0333 (Electronic)
IS  - 1464-0325 (Linking)
VI  - 12
IP  - 10
DP  - 2010 Oct 6
TI  - Simultaneous quantitation of parabens, triclosan, and methyl triclosan in indoor 
      house dust using solid phase extraction and gas chromatography-mass spectrometry.
PG  - 1891-7
LID - 10.1039/c0em00189a [doi]
AB  - An integrated analytical method for the simultaneous determination of five 
      parabens (methyl-, ethyl-, propyl-, butyl-, and benzyl-), triclosan, and methyl 
      triclosan in indoor house dust was developed based on gas chromatographic-mass 
      spectrometric technique (GC/MS). Analytes were extracted from dust samples by 
      sonication. After sample cleanup by solid-phase extraction (SPE), the extracts 
      were derivatized with N-methyl-N-(trimethylsilyl)trifluoroacetamide (MSTFA) and 
      then analyzed by gas chromatography coupled with ion trap mass spectrometry 
      operated in multiple reaction monitoring (MRM) mode. For quantitation, 
      isotope-labelled internal standards were used for each corresponding target 
      analyte. Only 0.05 g of dust sample was needed for the analysis. Method detection 
      limits ranged from 6.5 to 10 ng/g, and absolute recoveries from 74% to 92%. The 
      developed method demonstrated good repeatability and reproducibility, with 
      relative standard deviations (RSDs) less than 16% for all the analytes. The 
      analytes were determined in dust samples collected using two vacuum sampling 
      methods from 63 Canadian homes: a sample of fresh or "active" dust (FD) collected 
      using a Pullman-Holt vacuum sampler, and a composite sample taken from the 
      household vacuum cleaner (HD). Methyl paraben, propyl paraben, and triclosan were 
      detected in all HD and FD samples. HD samples yielded median values for methyl 
      paraben, propyl paraben, and triclosan of 1080, 463, and 378 ng/g, respectively, 
      which were comparable to the FD sample medians of 1120, 618 and 571 ng/g. Ethyl 
      paraben was detected at frequencies of 89% in FD and 73% in HD samples, with 
      median values of 52 and 25 ng/g, respectively. Butyl paraben was detected at 
      frequencies of 44% in FD and 75% in HD samples, with median values of <10 and 59 
      ng/g, respectively. Benzyl paraben and methyl triclosan were not detected in any 
      of the samples collected by either method. Samples collected according to the 
      fresh dust protocol agreed with the household vacuum samples 90% of the time. 
      Widely scattered concentration levels were observed for target analytes from this 
      preliminary set of 63 Canadian samples, which suggests a wide variability in 
      Canadian household exposures to these chemicals.
FAU - Fan, Xinghua
AU  - Fan X
AD  - Health Canada, Healthy Environments and Consumer Safety Branch, Environmental 
      Health Science and Research Bureau, Ottawa, Ontario, Canada.
FAU - Kubwabo, Cariton
AU  - Kubwabo C
FAU - Rasmussen, Pat
AU  - Rasmussen P
FAU - Jones-Otazo, Heather
AU  - Jones-Otazo H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100906
PL  - England
TA  - J Environ Monit
JT  - Journal of environmental monitoring : JEM
JID - 100968688
RN  - 0 (Dust)
RN  - 0 (Parabens)
RN  - 4NM5039Y5X (Triclosan)
RN  - 5174UR1DP5 (methyl triclosan)
SB  - IM
MH  - Air Pollution, Indoor/*analysis
MH  - Dust/*analysis
MH  - *Environmental Monitoring
MH  - Gas Chromatography-Mass Spectrometry
MH  - Parabens/*analysis/chemistry
MH  - Solid Phase Extraction
MH  - Triclosan/*analogs & derivatives/*analysis/chemistry
EDAT- 2010/09/08 06:00
MHDA- 2011/01/25 06:00
CRDT- 2010/09/08 06:00
PHST- 2010/09/08 06:00 [entrez]
PHST- 2010/09/08 06:00 [pubmed]
PHST- 2011/01/25 06:00 [medline]
AID - 10.1039/c0em00189a [doi]
PST - ppublish
SO  - J Environ Monit. 2010 Oct 6;12(10):1891-7. doi: 10.1039/c0em00189a. Epub 2010 Sep 
      6.