PMID- 20821418
OWN - NLM
STAT- MEDLINE
DCOM- 20100923
LR  - 20181201
IS  - 0730-7268 (Print)
IS  - 0730-7268 (Linking)
VI  - 29
IP  - 1
DP  - 2010 Jan
TI  - Multimedia modeling of human exposure to chemical substances: the roles of food 
      web biomagnification and biotransformation.
PG  - 45-55
LID - 10.1002/etc.15 [doi]
AB  - The Risk Assessment IDentification And Ranking (RAIDAR) model is refined to 
      calculate relative human exposures as expressed by total intake, intake fraction 
      (iF), and total body burden (TBB) metrics. The RAIDAR model is applied to three 
      persistent organic pollutants (POPs) and six petrochemicals using four 
      mode-of-entry emission scenarios to evaluate the effect of metabolic 
      biotransformation estimates on human exposure calculations. When 
      biotransformation rates are assumed to be negligible, daily intake and iFs for 
      the nine substances ranged over six orders of magnitude and TBBs ranged over 10 
      orders of magnitude. Including biotransformation estimates for fish, birds, and 
      mammals reduced substance-specific daily intake and iF by up to 4.5 orders of 
      magnitude and TBB by more than eight orders of magnitude. The RAIDAR iF 
      calculations are compared to the European Union System for the Evaluation of 
      Substances (EUSES) model iF calculations and differences are discussed, 
      especially the treatment of food web bioaccumulation. Model selection and 
      application assumptions result in different rankings of human exposure potential. 
      These results suggest a need to critically consider model selection and to 
      include reliable biotransformation rate estimates when assessing relative human 
      exposure and ranking substances for priority setting. Recommendations for further 
      model evaluations and revisions are discussed.
FAU - Arnot, Jon A
AU  - Arnot JA
AD  - Centre for Environmental Modelling and Chemistry, Trent University, 1600 West 
      Bank Drive, Peterborough, Ontario K9J7B8, Canada. jonarnot@trentu.ca
FAU - Mackay, Don
AU  - Mackay D
FAU - Parkerton, Thomas F
AU  - Parkerton TF
FAU - Zaleski, Rosemary T
AU  - Zaleski RT
FAU - Warren, Christopher S
AU  - Warren CS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Environ Toxicol Chem
JT  - Environmental toxicology and chemistry
JID - 8308958
RN  - 0 (Heptanes)
RN  - 59NEE7PCAB (Hexachlorocyclohexane)
RN  - A8289P68Y2 (2,2,4,6,6-pentamethylheptane)
SB  - IM
MH  - Biotransformation
MH  - Body Burden
MH  - *Environmental Exposure
MH  - *Food Chain
MH  - Heptanes/toxicity
MH  - Hexachlorocyclohexane/toxicity
MH  - Humans
MH  - Models, Biological
MH  - Multimedia
MH  - *Risk Assessment
EDAT- 2010/09/08 06:00
MHDA- 2010/09/24 06:00
CRDT- 2010/09/08 06:00
PHST- 2010/09/08 06:00 [entrez]
PHST- 2010/09/08 06:00 [pubmed]
PHST- 2010/09/24 06:00 [medline]
AID - 10.1002/etc.15 [doi]
PST - ppublish
SO  - Environ Toxicol Chem. 2010 Jan;29(1):45-55. doi: 10.1002/etc.15.