PMID- 20821568
OWN - NLM
STAT- MEDLINE
DCOM- 20101227
LR  - 20161018
IS  - 1552-8618 (Electronic)
IS  - 0730-7268 (Linking)
VI  - 29
IP  - 6
DP  - 2010 Jun
TI  - Tissue-specific distribution and whole-body burden estimates of persistent 
      organic pollutants in the bottlenose dolphin (Tursiops truncatus).
PG  - 1263-73
LID - 10.1002/etc.152 [doi]
AB  - Most exposure assessments for free-ranging cetaceans focus on contaminant 
      concentrations measured in blubber, and few data are available for other tissues 
      or the factors governing contaminant distribution among tissues. The goal of this 
      study was to provide a detailed description of the distribution of persistent 
      organic pollutants (POPs) within the common bottlenose dolphin (Tursiops 
      truncatus) body and assess the role of lipid dynamics in mediating contaminant 
      distribution. Thirteen tissues (brain, blubber, heart, liver, lung, kidney, 
      mammary gland, melon, skeletal muscle, spleen, thyroid, thymus, and 
      testis/uterus) were sampled during necropsy from bottlenose dolphins (n = 4) and 
      analyzed for lipid and 85 POPs, including polychlorinated biphenyls, 
      organochlorine pesticides, and polybrominated diphenyl ethers. Significant 
      correlations between tissue POP concentrations and lipid suggest that 
      distribution of POPs is generally related to tissue lipid content. However, 
      blubber:tissue partition coefficients ranged widely from 0.753 to 6.25, 
      suggesting that contaminant distribution is not entirely lipid-dependent. 
      Tissue-specific and whole-body contaminant burdens confirmed that blubber, the 
      primary site of metabolic lipid storage, is also the primary site for POP 
      accumulation, contributing >90% to the whole-body burdens. Observations also 
      suggest that as lipid mobilizes from blubber, contaminants may redistribute, 
      leading to elevated tissue concentrations. These results suggest that individuals 
      with reduced blubber lipid may be at increased risk for exposure-related health 
      effects. However, this study also provides evidence that the melon, a 
      metabolically inert lipid-rich structure, may serve as an alternate depot for 
      POPs, thus preventing the bulk of blubber contaminants from being directly 
      available to other tissues. This unique physiological adaptation should be taken 
      into consideration when assessing contaminant-related health effects in wild 
      cetacean populations.
CI  - Copyright 2010 SETAC.
FAU - Yordy, Jennifer E
AU  - Yordy JE
AD  - Marine Biomedicine and Environmental Sciences Center, Medical University of South 
      Carolina, 221 Fort Johnson Rd., Charleston, South Carolina 29412, USA. 
      jennifer.yordy@noaa.gov
FAU - Pabst, D Ann
AU  - Pabst DA
FAU - McLellan, William A
AU  - McLellan WA
FAU - Wells, Randall S
AU  - Wells RS
FAU - Rowles, Teri K
AU  - Rowles TK
FAU - Kucklick, John R
AU  - Kucklick JR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Environ Toxicol Chem
JT  - Environmental toxicology and chemistry
JID - 8308958
RN  - 0 (Organic Chemicals)
SB  - IM
MH  - Animals
MH  - Body Burden
MH  - Bottle-Nosed Dolphin/*metabolism
MH  - Environmental Pollution/*analysis
MH  - Organic Chemicals/*analysis/*pharmacokinetics
MH  - Tissue Distribution
EDAT- 2010/09/08 06:00
MHDA- 2010/12/28 06:00
CRDT- 2010/09/08 06:00
PHST- 2010/09/08 06:00 [entrez]
PHST- 2010/09/08 06:00 [pubmed]
PHST- 2010/12/28 06:00 [medline]
AID - 10.1002/etc.152 [doi]
PST - ppublish
SO  - Environ Toxicol Chem. 2010 Jun;29(6):1263-73. doi: 10.1002/etc.152.