PMID- 20822909
OWN - NLM
STAT- MEDLINE
DCOM- 20110310
LR  - 20221207
IS  - 1532-2653 (Electronic)
IS  - 0967-5868 (Linking)
VI  - 17
IP  - 12
DP  - 2010 Dec
TI  - The rs522616 polymorphism in the matrix metalloproteinase-3 (MMP-3) gene is 
      associated with sporadic brain arteriovenous malformation in a Chinese 
      population.
PG  - 1568-72
LID - 10.1016/j.jocn.2010.04.023 [doi]
AB  - In this study, we investigated the association between common variants in the 
      matrix metalloproteinase-3 (MMP-3) gene and the risk of developing sporadic brain 
      arteriovenous malformation (BAVM). We performed genotyping analyses for five 
      single nucleotide polymorphisms (SNPs) in MMP-3 in a case-control study involving 
      319 Chinese patients with BAVM and 333 Chinese controls. The association between 
      MMP-3 genotypes and the risk of developing BAVM was evaluated using logistic 
      regression analyses. We found that the genotype frequencies were significantly 
      different between patients and controls for the rs522616 A > G variant of MMP-3 
      (p = 0.02). Logistic regression analysis revealed that the variant genotype of 
      this polymorphism was associated with a significantly decreased risk of BAVM 
      (adjusted odds ratio = 0.62, 95% confidence interval = 0.44-0.87, p = 0.006 for 
      the AG compared with the AA genotype; adjusted odds ratio=0.68, 95% confidence 
      interval = 0.49-0.94, p = 0.019 for the AG + GG compared with the AA genotype). 
      These findings indicate for the first time that the MMP-3 rs522616 polymorphism 
      may contribute to the etiology of sporadic BAVM in the Chinese population.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Zhao, Yao
AU  - Zhao Y
AD  - Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan 
      University, Shanghai 200040, China.
FAU - Li, Peiliang
AU  - Li P
FAU - Fan, Weiwei
AU  - Fan W
FAU - Chen, Dan
AU  - Chen D
FAU - Gu, Yuxiang
AU  - Gu Y
FAU - Lu, Daru
AU  - Lu D
FAU - Zhao, Fan
AU  - Zhao F
FAU - Hu, Jin
AU  - Hu J
FAU - Fu, Chaowei
AU  - Fu C
FAU - Chen, Xiancheng
AU  - Chen X
FAU - Zhou, Liangfu
AU  - Zhou L
FAU - Mao, Ying
AU  - Mao Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100906
PL  - Scotland
TA  - J Clin Neurosci
JT  - Journal of clinical neuroscience : official journal of the Neurosurgical Society 
      of Australasia
JID - 9433352
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adult
MH  - Asian People/*genetics
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Intracranial Arteriovenous Malformations/enzymology/*genetics
MH  - Male
MH  - Matrix Metalloproteinase 3/*genetics
MH  - Odds Ratio
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Single Nucleotide
EDAT- 2010/09/09 06:00
MHDA- 2011/03/11 06:00
CRDT- 2010/09/09 06:00
PHST- 2010/02/07 00:00 [received]
PHST- 2010/03/29 00:00 [revised]
PHST- 2010/04/04 00:00 [accepted]
PHST- 2010/09/09 06:00 [entrez]
PHST- 2010/09/09 06:00 [pubmed]
PHST- 2011/03/11 06:00 [medline]
AID - S0967-5868(10)00358-9 [pii]
AID - 10.1016/j.jocn.2010.04.023 [doi]
PST - ppublish
SO  - J Clin Neurosci. 2010 Dec;17(12):1568-72. doi: 10.1016/j.jocn.2010.04.023. Epub 
      2010 Sep 6.