PMID- 20823625
OWN - NLM
STAT- MEDLINE
DCOM- 20110613
LR  - 20190608
IS  - 1880-8026 (Electronic)
IS  - 0019-8366 (Linking)
VI  - 49
IP  - 1
DP  - 2011
TI  - Occupational exposure in methyl bromide manufacturing workers: 17-year follow-up 
      study of urinary bromide ion concentration for biological monitoring.
PG  - 133-8
AB  - To elucidate the circumstances of their occupational exposure to methyl bromide 
      (MeBr), we conducted a 17-yr study on 124 workers employed by a MeBr 
      manufacturer. Subjects were classified into three groups according to the nature 
      of their work: synthesis group, filling group, and other group. Urinary 
      concentrations of bromide ion (Br(-)) were assessed, and data attained via 
      MeBr-health examinations were analyzed. The highest Br(-) concentrations were 
      seen in the synthesis group, with a median value of 13.0 mug/mg CRE (2.5-51.8), 
      followed by the filling group, with a concentration of 11.9 mug/mg CRE (3.1-34.8). 
      Both values were significantly higher than the levels noted in the other group 
      (p<0.001). Three major opportunities for exposure were identified: during 
      exchange of reaction equipment for maintenance or cleaning, during operations to 
      adjust for weight variations after filling canisters, or when canisters were 
      recycled. Overall, however, the workplace environment concentration remained 
      largely below the administrative control level throughout the study period. 
      Therefore, while this was a relatively well-controlled workplace, exposure 
      opportunities still arose when performing certain tasks, indicating the need for 
      ongoing improvement in workplace procedures and underscoring the importance of 
      biological monitoring.
FAU - Yamano, Yuko
AU  - Yamano Y
AD  - Department of Hygiene and Preventive Medicine, Showa University School of 
      Medicine, Tokyo 142-8555, Japan. yamano@med.showa-u.ac.jp
FAU - Tokutake, Tomoko
AU  - Tokutake T
FAU - Ishizu, Sumiko
AU  - Ishizu S
FAU - Nakadate, Toshio
AU  - Nakadate T
LA  - eng
PT  - Journal Article
DEP - 20100901
PL  - Japan
TA  - Ind Health
JT  - Industrial health
JID - 2985065R
RN  - 0 (Bromides)
RN  - 0 (Hydrocarbons, Brominated)
RN  - 9V42E1Z7B6 (methyl bromide)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Bromides/*urine
MH  - *Chemical Industry
MH  - Environmental Monitoring
MH  - Follow-Up Studies
MH  - Humans
MH  - Hydrocarbons, Brominated/*adverse effects
MH  - Middle Aged
MH  - *Occupational Exposure
MH  - Time Factors
MH  - Young Adult
EDAT- 2010/09/09 06:00
MHDA- 2011/06/15 06:00
CRDT- 2010/09/09 06:00
PHST- 2010/09/09 06:00 [entrez]
PHST- 2010/09/09 06:00 [pubmed]
PHST- 2011/06/15 06:00 [medline]
AID - JST.JSTAGE/indhealth/MS1143 [pii]
AID - 10.2486/indhealth.ms1143 [doi]
PST - ppublish
SO  - Ind Health. 2011;49(1):133-8. doi: 10.2486/indhealth.ms1143. Epub 2010 Sep 1.