PMID- 20824664
OWN - NLM
STAT- MEDLINE
DCOM- 20110526
LR  - 20131121
IS  - 1613-4133 (Electronic)
IS  - 1613-4125 (Linking)
VI  - 55
IP  - 2
DP  - 2011 Feb
TI  - The insulin sensitivity response is determined by the interaction between the 
      G972R polymorphism of the insulin receptor substrate 1 gene and dietary fat.
PG  - 328-35
LID - 10.1002/mnfr.201000235 [doi]
AB  - SCOPE: Insulin resistance, a condition associated with type 2 diabetes mellitus, 
      results from the interaction of environmental and genetic factors. The aim of 
      this study was to explore the influence of the G972R polymorphism at the insulin 
      receptor substrate 1 gene on insulin sensitivity in a healthy young population. 
      Furthermore, we examined whether the presence of this single nucleotide 
      polymorphism (SNP; GR or GG) interacts with dietary fat to modulate insulin 
      sensitivity. METHODS AND RESULTS: Fifty-nine healthy volunteers consumed three 
      diets during 4 wk each following a randomized crossover design: a saturated fatty 
      acid diet, a low-fat and high carbohydrate (CHO) diet or a MUFA diet. For each 
      diet, we investigated peripheral insulin sensitivity with the insulin suppression 
      test. Steady-state plasma glucose and plasma-free fatty acids concentrations were 
      significantly lower in GR subjects after the intake of a CHO diet, than did 
      homozygous GG subjects (p<0.05). However, no differences were observed after 
      consuming the two other diets. CONCLUSIONS: Insulin sensitivity increased in GR 
      subjects for the G972R polymorphism at the insulin receptor substrate 1 gene 
      locus, after intake of a CHO diet. Increased knowledge of how these and other 
      genes influence insulin sensitivity should increase the understanding of 
      personalized nutrition.
CI  - Copyright (c) 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Marin, Carmen
AU  - Marin C
AD  - Lipids and Atherosclerosis Unit, Instituto Maimonides de Investigacion Biomedica 
      de Cordoba (IMIBIC)/Hospital Universitario Reina Sofia/Universidad de Cordoba and 
      Ciber Fisiopatologia Obesidad y Nutricion, Instituto Salud Carlos III, Cordoba, 
      Spain.
FAU - Perez-Martinez, Pablo
AU  - Perez-Martinez P
FAU - Delgado-Lista, Javier
AU  - Delgado-Lista J
FAU - Gomez, Purificacion
AU  - Gomez P
FAU - Rodriguez, Fernando
AU  - Rodriguez F
FAU - Yubero-Serrano, Elena Maria
AU  - Yubero-Serrano EM
FAU - Garcia-Rios, Antonio
AU  - Garcia-Rios A
FAU - Camargo, Antonio
AU  - Camargo A
FAU - Perez-Jimenez, Francisco
AU  - Perez-Jimenez F
FAU - Lopez-Miranda, Jose
AU  - Lopez-Miranda J
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20100907
PL  - Germany
TA  - Mol Nutr Food Res
JT  - Molecular nutrition & food research
JID - 101231818
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
RN  - 0 (Fatty Acids, Monounsaturated)
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 0 (IRS1 protein, human)
RN  - 0 (Insulin Receptor Substrate Proteins)
RN  - 0 (Lipoproteins)
RN  - 0 (lipoprotein cholesterol)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Adult
MH  - Blood Glucose/analysis
MH  - Body Mass Index
MH  - Cholesterol/blood
MH  - Cross-Over Studies
MH  - Diet, Fat-Restricted
MH  - Dietary Carbohydrates/administration & dosage
MH  - Dietary Fats/*administration & dosage
MH  - Fatty Acids, Monounsaturated/administration & dosage
MH  - Fatty Acids, Nonesterified/blood
MH  - Female
MH  - Genetic Association Studies
MH  - Heterozygote
MH  - Humans
MH  - Insulin Receptor Substrate Proteins/*genetics
MH  - Insulin Resistance/*genetics
MH  - Lipoproteins/blood
MH  - Male
MH  - *Polymorphism, Single Nucleotide
MH  - Spain
MH  - Young Adult
EDAT- 2010/09/09 06:00
MHDA- 2011/05/27 06:00
CRDT- 2010/09/09 06:00
PHST- 2010/05/22 00:00 [received]
PHST- 2010/07/17 00:00 [revised]
PHST- 2010/07/19 00:00 [accepted]
PHST- 2010/09/09 06:00 [entrez]
PHST- 2010/09/09 06:00 [pubmed]
PHST- 2011/05/27 06:00 [medline]
AID - 10.1002/mnfr.201000235 [doi]
PST - ppublish
SO  - Mol Nutr Food Res. 2011 Feb;55(2):328-35. doi: 10.1002/mnfr.201000235. Epub 2010 
      Sep 7.