PMID- 20824740
OWN - NLM
STAT- MEDLINE
DCOM- 20101029
LR  - 20231129
IS  - 1531-4995 (Electronic)
IS  - 0023-852X (Linking)
VI  - 120
IP  - 10
DP  - 2010 Oct
TI  - Optical coherence tomography allows for the reliable identification of laryngeal 
      epithelial dysplasia and for precise biopsy: a clinicopathological study of 61 
      patients undergoing microlaryngoscopy.
PG  - 1964-70
LID - 10.1002/lary.21057 [doi]
AB  - OBJECTIVES/HYPOTHESIS: A newly developed microscope-based spectral-domain optical 
      coherence tomography (SD-OCT) device and an endoscope-based time-domain OCT 
      (TD-OCT) were used to assess the inter-rater reliability, sensitivity, 
      specificity, and accuracy of benign and dysplastic laryngeal epithelial lesions. 
      STUDY DESIGN: Prospective study. METHODS: OCT during microlaryngoscopy was done 
      on 35 patients with an endoscope-based TD-OCT, and on 26 patients by an SD-OCT 
      system integrated into an operating microscope. Biopsies were taken from 
      microscopically suspicious lesions allowing comparative study of OCT images and 
      histology. RESULTS: Thickness of the epithelium was seen to be the main criterion 
      for degree of dysplasia. The inter-rater reliability for two observers was found 
      to be kappa = 0.74 (P <.001) for OCT. OCT provided test outcomes for 
      differentiation between benign laryngeal lesions and dysplasia/CIS with 
      sensitivity of 88%, specificity of 89%, PPV of 85%, NPV of 91%, and predictive 
      accuracy of 88%. However, because of the limited penetration depth of the laser 
      light primarily in hyperkeratotic lesions (thickness above 1.5 mm), the basal 
      cell layer was no longer visible, precluding reliable assessment of such lesions. 
      CONCLUSIONS: OCT allows for a fairly accurate assessment of benign and dysplastic 
      laryngeal epithelial lesion and greatly facilitates the taking of precise 
      biopsies. Laryngoscope, 2010.
FAU - Just, Tino
AU  - Just T
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, University of Rostock, 
      Rostock, Germany. tino.just@med.unirostock.de
FAU - Lankenau, Eva
AU  - Lankenau E
FAU - Prall, Friedrich
AU  - Prall F
FAU - Huttmann, Gereon
AU  - Huttmann G
FAU - Pau, Hans Wilhelm
AU  - Pau HW
FAU - Sommer, Konrad
AU  - Sommer K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Laryngoscope
JT  - The Laryngoscope
JID - 8607378
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Biopsy
MH  - Female
MH  - Humans
MH  - Laryngeal Diseases/*pathology
MH  - Laryngoscopy/*methods
MH  - Male
MH  - Middle Aged
MH  - Precancerous Conditions/*pathology
MH  - Prospective Studies
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - *Tomography, Optical Coherence
EDAT- 2010/09/09 06:00
MHDA- 2010/10/30 06:00
CRDT- 2010/09/09 06:00
PHST- 2010/09/09 06:00 [entrez]
PHST- 2010/09/09 06:00 [pubmed]
PHST- 2010/10/30 06:00 [medline]
AID - 10.1002/lary.21057 [doi]
PST - ppublish
SO  - Laryngoscope. 2010 Oct;120(10):1964-70. doi: 10.1002/lary.21057.