PMID- 20824798
OWN - NLM
STAT- MEDLINE
DCOM- 20110204
LR  - 20220310
IS  - 2151-4658 (Electronic)
IS  - 2151-464X (Linking)
VI  - 63
IP  - 1
DP  - 2011 Jan
TI  - Effects of community-deliverable exercise on pain and physical function in adults 
      with arthritis and other rheumatic diseases: a meta-analysis.
PG  - 79-93
LID - 10.1002/acr.20347 [doi]
AB  - OBJECTIVE: To use the meta-analytic approach to determine the effects of 
      community-deliverable exercise on pain and physical function in adults with 
      arthritis and other rheumatic diseases (AORD). METHODS: Data sources consisted of 
      6 electronic databases, cross-referencing from retrieved studies and expert 
      review. Study selection included 1) randomized controlled trials; 2) >/= 1 exercise 
      intervention group; 3) community-deliverable exercise interventions >/= 4 weeks in 
      duration; 4) control group; 5) adults ages >/= 18 years with rheumatoid arthritis, 
      osteoarthritis, fibromyalgia, lupus, gout, or ankylosing spondylitis; 6) 
      published and unpublished studies; 7) studies published in any language between 
      January 1, 1980, and January 1, 2008; and 8) data available for pain and/or 
      physical function. Data abstraction included dual coding by 2 of the authors. 
      Standardized effect sizes (g) and random-effects models were used to pool pain 
      and physical function outcomes. Data were analyzed according to per-protocol and 
      intent-to-treat (ITT) results. The minimally clinically important difference 
      (MCID) and number needed to treat (NNT) were also calculated. RESULTS: 
      Thirty-three studies representing 3,180 men and women (1,857 exercise, 1,323 
      control) with rheumatoid arthritis, osteoarthritis, and fibromyalgia were 
      included. Statistically significant and clinically important improvements were 
      observed for pain (per-protocol g = -0.37 [95% confidence interval (95% CI) 
      -0.53, -0.21], MCID -18%; ITT g = -0.20 [95% CI -0.33, -0.07], MCID -9%, NNT 9) 
      and physical function (per-protocol g = 0.37 [95% CI 0.21, 0.52], MCID 15%; ITT g 
      = 0.34 [95% CI 0.25, 0.43], MCID 10%, NNT 5). CONCLUSION: Community-deliverable 
      exercise improves pain and physical function in adults with the types of AORD 
      included in the analysis. Dose-response as well as studies in those with other 
      types of AORD is needed.
CI  - Copyright (c) 2011 by the American College of Rheumatology.
FAU - Kelley, George A
AU  - Kelley GA
AD  - Meta-Analytic Research Group, School of Medicine, Department of Community 
      Medicine, Robert C. Byrd Health Sciences Center, West Virginia University, PO Box 
      9190, Morgantown, WV 26506-9190, USA. gkelley@hsc.wvu.edu
FAU - Kelley, Kristi S
AU  - Kelley KS
FAU - Hootman, Jennifer M
AU  - Hootman JM
FAU - Jones, Dina L
AU  - Jones DL
LA  - eng
GR  - U36/CCU319276/PHS HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Arthritis Care Res (Hoboken)
JT  - Arthritis care & research
JID - 101518086
SB  - IM
MH  - Adult
MH  - Arthritis
MH  - Arthritis, Rheumatoid/complications/physiopathology/therapy
MH  - *Community Health Services/methods
MH  - Exercise/*physiology
MH  - Exercise Therapy/methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Pain/etiology/physiopathology
MH  - *Pain Management
MH  - Randomized Controlled Trials as Topic/methods
MH  - Rheumatic Diseases/complications/physiopathology/*therapy
MH  - Treatment Outcome
EDAT- 2010/09/09 06:00
MHDA- 2011/02/05 06:00
CRDT- 2010/09/09 06:00
PHST- 2010/09/09 06:00 [entrez]
PHST- 2010/09/09 06:00 [pubmed]
PHST- 2011/02/05 06:00 [medline]
AID - 10.1002/acr.20347 [doi]
PST - ppublish
SO  - Arthritis Care Res (Hoboken). 2011 Jan;63(1):79-93. doi: 10.1002/acr.20347.