PMID- 20832059
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20211020
IS  - 1090-2163 (Electronic)
IS  - 0008-8749 (Print)
IS  - 0008-8749 (Linking)
VI  - 265
IP  - 2
DP  - 2010
TI  - Vitamin A deficiency alters splenic dendritic cell subsets and increases 
      CD8(+)Gr-1(+) memory T lymphocytes in C57BL/6J mice.
PG  - 156-63
LID - 10.1016/j.cellimm.2010.08.006 [doi]
AB  - Vitamin A-deficient populations have impaired T cell-dependent antibody 
      responses. Dendritic cells (DCs) are the most proficient antigen-presenting cells 
      to naive T cells. In the mouse, CD11b(+) myeloid DCs stimulate T helper (Th) 2 
      antibody immune responses, while CD8alpha(+) lymphoid DCs stimulate Th1 cell-mediated 
      immune responses. Therefore, we hypothesized that vitamin A-deficient animals 
      would have decreased numbers of myeloid DCs and unaffected numbers of lymphoid 
      DCs. We performed dietary depletion of vitamin A in C57BL/6J male and female mice 
      and used multicolor flow cytometry to quantify immune cell populations of the 
      spleen, with particular focus on DC subpopulations. We show that vitamin 
      A-depleted animals have increased polymorphonuclear neutrophils, lymphoid DCs, 
      and memory CD8(+) T cells and decreased CD4(+) T lymphocytes. Therefore, vitamin 
      A deficiency alters splenic DC subpopulations, which may contribute to skewed 
      immune responses of vitamin A-deficient populations.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Duriancik, David M
AU  - Duriancik DM
AD  - Department of Food Science and Human Nutrition, Michigan State University, East 
      Lansing, MI 48824, USA.
FAU - Hoag, Kathleen A
AU  - Hoag KA
LA  - eng
GR  - R21 AI058994/AI/NIAID NIH HHS/United States
GR  - R21 AI058994-02/AI/NIAID NIH HHS/United States
PT  - Journal Article
DEP - 20100824
PL  - Netherlands
TA  - Cell Immunol
JT  - Cellular immunology
JID - 1246405
RN  - 0 (CD11b Antigen)
SB  - IM
MH  - Animals
MH  - CD11b Antigen
MH  - CD4-Positive T-Lymphocytes/immunology/pathology
MH  - CD8-Positive T-Lymphocytes/*immunology/pathology
MH  - Dendritic Cells/*immunology/pathology
MH  - Female
MH  - Flow Cytometry
MH  - Immunologic Memory
MH  - Immunophenotyping
MH  - Lymphocyte Activation
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neutrophils/immunology/pathology
MH  - Spleen/immunology/pathology
MH  - Vitamin A Deficiency/*immunology/pathology
PMC - PMC2966341
MID - NIHMS244059
EDAT- 2010/09/14 06:00
MHDA- 2010/11/17 06:00
PMCR- 2011/01/01
CRDT- 2010/09/14 06:00
PHST- 2010/03/31 00:00 [received]
PHST- 2010/08/12 00:00 [revised]
PHST- 2010/08/19 00:00 [accepted]
PHST- 2010/09/14 06:00 [entrez]
PHST- 2010/09/14 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
PHST- 2011/01/01 00:00 [pmc-release]
AID - S0008-8749(10)00207-8 [pii]
AID - 10.1016/j.cellimm.2010.08.006 [doi]
PST - ppublish
SO  - Cell Immunol. 2010;265(2):156-63. doi: 10.1016/j.cellimm.2010.08.006. Epub 2010 
      Aug 24.