PMID- 20832869
OWN - NLM
STAT- MEDLINE
DCOM- 20101217
LR  - 20211203
IS  - 1872-8421 (Electronic)
IS  - 0165-5728 (Linking)
VI  - 229
IP  - 1-2
DP  - 2010 Dec 15
TI  - The role of non-HLA single nucleotide polymorphisms in multiple sclerosis 
      susceptibility.
PG  - 5-15
LID - 10.1016/j.jneuroim.2010.08.002 [doi]
AB  - Multiple sclerosis (MS) is the most common neurological disease of the central 
      nervous system affecting young adults. While the etiology of the disease is still 
      unknown, epidemiological and genetics studies have shown a significant inherited 
      component involved in MS pathogenesis. Single nucleotide polymorphisms (SNPs) 
      associated with MS have been recently evaluated by two main groups of 
      high-throughput genotyping analyses: candidate gene approaches and genome-wide 
      association studies (GWAS). Although both types of studies have identified 
      polymorphisms in the human leukocyte antigen (HLA) region as the strongest 
      susceptibility loci for MS, recent investigations have identified a broad 
      spectrum of non-HLA genes prominently associated with MS. This review will focus 
      on recent findings in non-HLA genes as well as their SNPs which have shown high 
      linkage to MS as a genetic-based disorder. Understanding of non-HLA polymorphisms 
      will help elucidate the signalling aberrations involved in MS development and may 
      help to identify novel, personalized approaches to therapy.
CI  - Copyright (c) 2010 Elsevier B.V. All rights reserved.
FAU - Bahreini, Seyed Amir
AU  - Bahreini SA
AD  - Department of Biology, Faculty of Sciences, University of Isfahan, Isfahan, Iran.
FAU - Jabalameli, M Reza
AU  - Jabalameli MR
FAU - Saadatnia, Mohammad
AU  - Saadatnia M
FAU - Zahednasab, Hamid
AU  - Zahednasab H
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100915
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
SB  - IM
MH  - Ethnicity/genetics
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genome-Wide Association Study
MH  - Humans
MH  - Multiple Sclerosis/epidemiology/ethnology/*genetics
MH  - Polymorphism, Single Nucleotide/*genetics
EDAT- 2010/09/14 06:00
MHDA- 2010/12/18 06:00
CRDT- 2010/09/14 06:00
PHST- 2010/05/13 00:00 [received]
PHST- 2010/07/19 00:00 [revised]
PHST- 2010/08/04 00:00 [accepted]
PHST- 2010/09/14 06:00 [entrez]
PHST- 2010/09/14 06:00 [pubmed]
PHST- 2010/12/18 06:00 [medline]
AID - S0165-5728(10)00346-2 [pii]
AID - 10.1016/j.jneuroim.2010.08.002 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2010 Dec 15;229(1-2):5-15. doi: 10.1016/j.jneuroim.2010.08.002. 
      Epub 2010 Sep 15.