PMID- 20832917
OWN - NLM
STAT- MEDLINE
DCOM- 20110203
LR  - 20101011
IS  - 1768-3254 (Electronic)
IS  - 0223-5234 (Linking)
VI  - 45
IP  - 11
DP  - 2010 Nov
TI  - The preparation of bi-functional organophosphine oxides as potential antitumor 
      agents.
PG  - 5527-30
LID - 10.1016/j.ejmech.2010.08.038 [doi]
AB  - Following our previously reported pyridinyl phosphine oxides as antitumor agents, 
      we targeted the commercially available C(2)-axial chiral organophosphine ligand 
      catalysts, such as 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl (BINAP) 1 and 
      2,2',6,6'-tetramethoxy-4,4'-bis(diphenylphosphino)-3,3'-bipyridine (P-Phos) 2 as 
      a convenient source for producing organophosphine oxides as antitumor leads. 
      Their corresponding chiral and racemic bi-phosphine oxides 3 and 4 can be 
      obtained easily through a simple oxidation step with hydrogen peroxide, and their 
      antitumor activities towards human hepatocellular carcinoma Hep3B cell line were 
      reported. We found out that compound 3 shows stronger antitumor activity than 
      that of 4, where axial chirality cannot improve their activity. Further athymic 
      nude mice Hep3B xenograft model demonstrates the attractive in vivo antitumor 
      potential of 3.
CI  - Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.
FAU - Lam, Kim-Hung
AU  - Lam KH
AD  - Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic 
      University, Hong Kong, China. bcjoelam@inet.polyu.edu.hk
FAU - Chui, Chung-Hin
AU  - Chui CH
FAU - Gambari, Roberto
AU  - Gambari R
FAU - Wong, Raymond Siu-Ming
AU  - Wong RS
FAU - Cheng, Gregory Yin-Ming
AU  - Cheng GY
FAU - Lau, Fung-Yi
AU  - Lau FY
FAU - Lai, Paul Bo-San
AU  - Lai PB
FAU - Tong, See-Wai
AU  - Tong SW
FAU - Chan, Kit-Wah
AU  - Chan KW
FAU - Wong, Wai-Yeung
AU  - Wong WY
FAU - Chan, Albert Sun-Chi
AU  - Chan AS
FAU - Tang, Johnny Cheuk-On
AU  - Tang JC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100824
PL  - France
TA  - Eur J Med Chem
JT  - European journal of medicinal chemistry
JID - 0420510
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Organophosphorus Compounds)
RN  - 0 (Oxides)
SB  - IM
MH  - Antineoplastic Agents/*chemical synthesis/*pharmacology
MH  - Cell Line, Tumor
MH  - Humans
MH  - Magnetic Resonance Spectroscopy
MH  - Organophosphorus Compounds/*chemical synthesis/*pharmacology
MH  - Oxides/chemistry
MH  - Spectrometry, Mass, Electrospray Ionization
EDAT- 2010/09/14 06:00
MHDA- 2011/02/04 06:00
CRDT- 2010/09/14 06:00
PHST- 2010/07/19 00:00 [received]
PHST- 2010/08/03 00:00 [revised]
PHST- 2010/08/13 00:00 [accepted]
PHST- 2010/09/14 06:00 [entrez]
PHST- 2010/09/14 06:00 [pubmed]
PHST- 2011/02/04 06:00 [medline]
AID - S0223-5234(10)00616-1 [pii]
AID - 10.1016/j.ejmech.2010.08.038 [doi]
PST - ppublish
SO  - Eur J Med Chem. 2010 Nov;45(11):5527-30. doi: 10.1016/j.ejmech.2010.08.038. Epub 
      2010 Aug 24.