PMID- 20833077
OWN - NLM
STAT- MEDLINE
DCOM- 20110127
LR  - 20151119
IS  - 1532-8503 (Electronic)
IS  - 1051-2276 (Linking)
VI  - 20
IP  - 6
DP  - 2010 Nov
TI  - Anti-inflammatory properties of high-density lipoprotein cholesterol in chronic 
      hemodialysis patients: impact of intervention.
PG  - 368-76
LID - 10.1053/j.jrn.2010.07.003 [doi]
AB  - OBJECTIVE: Levels of high-density lipoprotein (HDL) cholesterol as well as its 
      functional roles are suppressed in chronic kidney disease because of ongoing 
      chronic microinflammatory state. We hypothesized that intervention aimed at 
      reducing inflammation may improve the levels and activity of HDL cholesterol as 
      well as survival of our patients. METHODS: In this prospective follow-up study, 
      we selected 67 patients (33 women, 34 men) on chronic hemodialysis (23.5 months 
      [range, 10 to 34], aged 67.5 years [range, 39 to 90 years]). Targeted examination 
      for asymptomatic infective foci or poor function of arterio-venous (AV)-fistula 
      was carried out after a detailed initial clinical examination in all patients. 
      Individual intervention was performed according to examination results. Blood was 
      drawn for analysis of HDL cholesterol; interleukin-6, its soluble receptor, 
      monocyte chemoattractant protein 1 (MCP-1), total iron binding capacity, and high 
      sensitivity C-reactive protein at the beginning of the study and after 3 months. 
      The patients were then closely followed up for 2 years during which the 
      occurrence and cause of death was registered. RESULTS: A significant decrease of 
      inflammatory parameters (Interleukin-6: 4.9 vs. 1.1 pg/mL, P > .001 and MCP-1: 
      397 vs. 310 pg/mL, P = .02) and increase of HDL cholesterol (1.22 +/- 0.55 vs. 1.33 
      +/- 0.55; P = .003) was seen in the entire study population. No difference in 
      survival was found between the different interventional groups. The 2-year death 
      rate was 37%. On using Kaplan-Meier analysis, a significantly better survival in 
      patients with increase of HDL cholesterol (77% vs. 50%; P = .013) and/or a 
      decrease of MCP-1 (81% vs. 53%; P = .04) was found after 3 months of 
      intervention. CONCLUSIONS: It was concluded that individually aimed intervention 
      may improve levels of HDL cholesterol and MCP-1. Changes in these 2 parameters 
      can predict the 2-year survival rates of patients.
CI  - Copyright (c) 2010 National Kidney Foundation, Inc. Published by Elsevier Inc. All 
      rights reserved.
FAU - Mistrik, Erik
AU  - Mistrik E
AD  - Department of Metabolic Care and Gerontology, University Hospital Hradec Kralove, 
      Charles University, Hradec Kralove, Czech Republic. erosito@gmail.com
FAU - Blaha, Vladimir
AU  - Blaha V
FAU - Dusilova-Sulkova, Sylvie
AU  - Dusilova-Sulkova S
FAU - Andrys, Ctirad
AU  - Andrys C
FAU - Kalousova, Marta
AU  - Kalousova M
FAU - Sobotka, Lubos
AU  - Sobotka L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100915
PL  - United States
TA  - J Ren Nutr
JT  - Journal of renal nutrition : the official journal of the Council on Renal 
      Nutrition of the National Kidney Foundation
JID - 9112938
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Interleukin-6)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Angioplasty, Balloon
MH  - Anti-Inflammatory Agents/*blood
MH  - Arteriovenous Shunt, Surgical
MH  - C-Reactive Protein/metabolism
MH  - Catheterization
MH  - Chemokine CCL2/metabolism
MH  - Cholesterol, HDL/*blood
MH  - Cholesterol, LDL/blood
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Interleukin-6/metabolism
MH  - Kidney Failure, Chronic/*mortality/*therapy
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Renal Dialysis
MH  - Survival Rate
EDAT- 2010/09/14 06:00
MHDA- 2011/01/29 06:00
CRDT- 2010/09/14 06:00
PHST- 2009/10/13 00:00 [received]
PHST- 2010/06/17 00:00 [revised]
PHST- 2010/07/12 00:00 [accepted]
PHST- 2010/09/14 06:00 [entrez]
PHST- 2010/09/14 06:00 [pubmed]
PHST- 2011/01/29 06:00 [medline]
AID - S1051-2276(10)00180-9 [pii]
AID - 10.1053/j.jrn.2010.07.003 [doi]
PST - ppublish
SO  - J Ren Nutr. 2010 Nov;20(6):368-76. doi: 10.1053/j.jrn.2010.07.003. Epub 2010 Sep 
      15.