PMID- 20833375
OWN - NLM
STAT- MEDLINE
DCOM- 20101213
LR  - 20211020
IS  - 1934-6069 (Electronic)
IS  - 1931-3128 (Linking)
VI  - 8
IP  - 3
DP  - 2010 Sep 16
TI  - Immune inhibitory ligand CD200 induction by TLRs and NLRs limits macrophage 
      activation to protect the host from meningococcal septicemia.
PG  - 236-47
LID - 10.1016/j.chom.2010.08.005 [doi]
AB  - Macrophage activation is essential for protection against bacterial pathogens but 
      needs to be regulated to prevent damage to the host. We show a key role for the 
      immune inhibitory receptor CD200R and its ligand CD200 in the context of 
      infection with the Gram-negative human pathogen Neisseria meningitidis. N. 
      meningitidis induced CD200 but downregulated CD200R on macrophages in a manner 
      dependent on Neisserial lipopolysaccharide, Toll-like receptor-4 (TLR-4), and the 
      MyD88 pathway but independent of a known Neisserial receptor, scavenger receptor 
      A (SR-A). Agonists of the pattern-recognition receptors nucleotide 
      oligomerization domain 2 (NOD2) and NACHT-LRR protein 3 (NALP3) also induced 
      CD200. The NF-kappaB member c-Rel was essential for TLR-, NOD2-, and NALP3-mediated 
      induction of CD200. CD200(-/-) animals showed higher lethality in response to 
      experimental meningococcal septicemia, induced higher levels of proinflammatory 
      cytokines, and recruited increased numbers of activated leukocytes, despite 
      comparable bacterial clearance. Thus CD200 is induced by TLR-, NOD2-, and 
      NALP3-mediated pathways, limiting their function and protecting the host from 
      excessive inflammation.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Mukhopadhyay, Subhankar
AU  - Mukhopadhyay S
AD  - Sir William Dunn School of Pathology, University of Oxford, South Parks Road, 
      Oxford, UK.
FAU - Pluddemann, Annette
AU  - Pluddemann A
FAU - Hoe, J Claire
AU  - Hoe JC
FAU - Williams, Kevin J
AU  - Williams KJ
FAU - Varin, Audrey
AU  - Varin A
FAU - Makepeace, Katherine
AU  - Makepeace K
FAU - Aknin, Marie-Laure
AU  - Aknin ML
FAU - Bowdish, Dawn M E
AU  - Bowdish DM
FAU - Smale, Stephen T
AU  - Smale ST
FAU - Barclay, A Neil
AU  - Barclay AN
FAU - Gordon, Siamon
AU  - Gordon S
LA  - eng
GR  - G0400808/MRC_/Medical Research Council/United Kingdom
GR  - G0500623/MRC_/Medical Research Council/United Kingdom
GR  - R01 AI073868/AI/NIAID NIH HHS/United States
GR  - WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cell Host Microbe
JT  - Cell host & microbe
JID - 101302316
RN  - 0 (Antigens, CD)
RN  - 0 (CD200 receptor, mouse)
RN  - 0 (Carrier Proteins)
RN  - 0 (Cytokines)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Myeloid Differentiation Factor 88)
RN  - 0 (NF-kappa B)
RN  - 0 (NLR Family, Pyrin Domain-Containing 3 Protein)
RN  - 0 (Nlrp3 protein, mouse)
RN  - 0 (Nod2 Signaling Adaptor Protein)
RN  - 0 (Nod2 protein, mouse)
RN  - 0 (Toll-Like Receptor 4)
RN  - 0 (Toll-Like Receptors)
RN  - UQ4V77A8VA (antigens, CD200)
SB  - IM
MH  - Animals
MH  - Antigens, CD/genetics/*metabolism
MH  - Carrier Proteins/*metabolism
MH  - Cytokines/metabolism
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Flow Cytometry
MH  - Gene Expression Regulation
MH  - Humans
MH  - Lipopolysaccharides/immunology
MH  - *Macrophage Activation
MH  - Macrophages, Peritoneal/*immunology/metabolism
MH  - Membrane Glycoproteins/genetics/*metabolism
MH  - Meningococcal Infections/*immunology
MH  - Mice
MH  - Myeloid Differentiation Factor 88/metabolism
MH  - NF-kappa B/metabolism
MH  - NLR Family, Pyrin Domain-Containing 3 Protein
MH  - Neisseria meningitidis/*immunology
MH  - Nod2 Signaling Adaptor Protein/*metabolism
MH  - Peritonitis/immunology
MH  - Sepsis/immunology
MH  - Signal Transduction
MH  - Toll-Like Receptor 4/metabolism
MH  - Toll-Like Receptors/*metabolism
EDAT- 2010/09/14 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/09/14 06:00
PHST- 2009/12/08 00:00 [received]
PHST- 2010/03/26 00:00 [revised]
PHST- 2010/07/15 00:00 [accepted]
PHST- 2010/09/14 06:00 [entrez]
PHST- 2010/09/14 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S1931-3128(10)00277-5 [pii]
AID - 10.1016/j.chom.2010.08.005 [doi]
PST - ppublish
SO  - Cell Host Microbe. 2010 Sep 16;8(3):236-47. doi: 10.1016/j.chom.2010.08.005.