PMID- 20833973
OWN - NLM
STAT- MEDLINE
DCOM- 20110222
LR  - 20220321
IS  - 1538-7755 (Electronic)
IS  - 1055-9965 (Print)
IS  - 1055-9965 (Linking)
VI  - 19
IP  - 11
DP  - 2010 Nov
TI  - No effect of exercise on insulin-like growth factor-I, insulin, and glucose in 
      young women participating in a 16-week randomized controlled trial.
PG  - 2987-90
LID - 10.1158/1055-9965.EPI-10-0828 [doi]
AB  - INTRODUCTION: Insulin-like growth factor I (IGF-I) and IGF binding protein 3 
      (IGFBP-3) have been associated with increased risk of breast cancer. METHODS: We 
      report our findings on the effects of 16 weeks of aerobic exercise on IGF axis 
      proteins, insulin, glucose, and insulin resistance of 319 young sedentary women. 
      Demographics, health surveys, body composition, dietary intake, and blood samples 
      were collected at baseline and 16 weeks. IGF-I and IGFBP-1, IGFBP-2, and IGFBP-3 
      were measured by ELISA. RESULTS: Exercise adherence was 88%. The dropout rates 
      for the exercise and control groups were 21.7% and 14.5%, respectively. There was 
      a small significant change from baseline in IGFBP-3 concentrations. IGFBP-3 
      levels decreased in controls and increased in exercisers. The between-group 
      difference was significant. No other changes were noted. CONCLUSION: Sixteen 
      weeks of exercise had minimum or no effect on IGF proteins of young women. 
      IMPACT: Our study supports findings from previous studies conducted in older 
      populations and raises the question of what type of intervention is needed to 
      change circulating levels of IGF proteins in humans.
CI  - (c)2010 AACR.
FAU - Arikawa, Andrea Y
AU  - Arikawa AY
AD  - Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN 
      55108, USA. aarikawa@umn.edu
FAU - Kurzer, Mindy S
AU  - Kurzer MS
FAU - Thomas, William
AU  - Thomas W
FAU - Schmitz, Kathryn H
AU  - Schmitz KH
LA  - eng
GR  - M01 RR000400/RR/NCRR NIH HHS/United States
GR  - R01 CA131333/CA/NCI NIH HHS/United States
GR  - U54 CA116849/CA/NCI NIH HHS/United States
GR  - M01-RR00400/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
DEP - 20100910
PL  - United States
TA  - Cancer Epidemiol Biomarkers Prev
JT  - Cancer epidemiology, biomarkers & prevention : a publication of the American 
      Association for Cancer Research, cosponsored by the American Society of 
      Preventive Oncology
JID - 9200608
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 0 (Insulin-Like Growth Factor Binding Protein 1)
RN  - 0 (Insulin-Like Growth Factor Binding Protein 2)
RN  - 0 (Insulin-Like Growth Factor Binding Protein 3)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Blood Glucose/*analysis/metabolism
MH  - Breast Neoplasms/blood/*prevention & control
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Exercise/*physiology
MH  - Female
MH  - Humans
MH  - Insulin/*blood
MH  - Insulin-Like Growth Factor Binding Protein 1/blood
MH  - Insulin-Like Growth Factor Binding Protein 2/blood
MH  - Insulin-Like Growth Factor Binding Protein 3/blood
MH  - Insulin-Like Growth Factor I/*analysis/metabolism
MH  - Young Adult
PMC - PMC2976790
MID - NIHMS234243
EDAT- 2010/09/14 06:00
MHDA- 2011/02/23 06:00
PMCR- 2011/11/01
CRDT- 2010/09/14 06:00
PHST- 2010/09/14 06:00 [entrez]
PHST- 2010/09/14 06:00 [pubmed]
PHST- 2011/02/23 06:00 [medline]
PHST- 2011/11/01 00:00 [pmc-release]
AID - 1055-9965.EPI-10-0828 [pii]
AID - 10.1158/1055-9965.EPI-10-0828 [doi]
PST - ppublish
SO  - Cancer Epidemiol Biomarkers Prev. 2010 Nov;19(11):2987-90. doi: 
      10.1158/1055-9965.EPI-10-0828. Epub 2010 Sep 10.