PMID- 20834170
OWN - NLM
STAT- MEDLINE
DCOM- 20110209
LR  - 20110811
IS  - 1347-6947 (Electronic)
IS  - 0916-8451 (Linking)
VI  - 74
IP  - 9
DP  - 2010
TI  - Inhibitory effects of heartwood extracts of Broussonetia kazinoki Sieb on the 
      development of atopic dermatitis in NC/Nga mice.
PG  - 1802-6
AB  - We investigated the effects of a topically applied extract of the heartwood of 
      Broussonetia kazinoki Sieb (B. kazinoki) on atopic dermatitis (AD)-like skin 
      lesions induced by an extract of the house-dust mite Dermatophagoides farina in 
      NC/Nga mice. We found that topically applied B. kazinoki extract suppressed the 
      histological manifestations of AD-like skin lesions, and decreased the levels of 
      plasma immunoglobulin E (IgE) and interleukin-4 (IL-4) in the mice. Moreover, B. 
      kazinoki inhibited the induction of thymus-and-activation-regulated chemokine 
      (TARC/CCL17), macrophage-derived chemokine (MDC/CCL22), and 
      regulated-on-activation-normal T cell-expressed-and-secreted chemokine 
      (RANTES/CCL5) in HaCaT cells activated by tumor necrosis factor-alpha (TNF-alpha) 
      and interferon-gamma (IFN-gamma). In conclusion, our results suggest that B. 
      kazinoki extract has therapeutic advantages in the treatment of AD.
FAU - Lee, Jun-Kyoung
AU  - Lee JK
AD  - Herbal Medicine EBM Research Center, Korea Institute of Oriental Medicine, 
      Daejeon, Republic of Korea.
FAU - Ha, Hyekyung
AU  - Ha H
FAU - Lee, Ho-Young
AU  - Lee HY
FAU - Park, Sang-Joon
AU  - Park SJ
FAU - Jeong, Seung-ll
AU  - Jeong SL
FAU - Choi, Young-Jae
AU  - Choi YJ
FAU - Shin, Hyeun Kyoo
AU  - Shin HK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100907
PL  - England
TA  - Biosci Biotechnol Biochem
JT  - Bioscience, biotechnology, and biochemistry
JID - 9205717
RN  - 0 (Ccl17 protein, mouse)
RN  - 0 (Ccl22 protein, mouse)
RN  - 0 (Ccl5 protein, mouse)
RN  - 0 (Chemokine CCL17)
RN  - 0 (Chemokine CCL22)
RN  - 0 (Chemokine CCL5)
RN  - 0 (Plant Extracts)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Administration, Topical
MH  - Animals
MH  - Broussonetia/*chemistry
MH  - Chemokine CCL17/analysis
MH  - Chemokine CCL22/analysis
MH  - Chemokine CCL5/analysis
MH  - Dermatitis, Atopic/*drug therapy
MH  - Immunoglobulin E/analysis
MH  - Interferon-gamma/pharmacology
MH  - Interleukin-4/analysis
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Phytotherapy
MH  - Plant Extracts/*therapeutic use
MH  - Plants, Medicinal
MH  - Pyroglyphidae/immunology/pathogenicity
MH  - Tumor Necrosis Factor-alpha/pharmacology
EDAT- 2010/09/14 06:00
MHDA- 2011/02/10 06:00
CRDT- 2010/09/14 06:00
PHST- 2010/09/14 06:00 [entrez]
PHST- 2010/09/14 06:00 [pubmed]
PHST- 2011/02/10 06:00 [medline]
AID - JST.JSTAGE/bbb/100138 [pii]
AID - 10.1271/bbb.100138 [doi]
PST - ppublish
SO  - Biosci Biotechnol Biochem. 2010;74(9):1802-6. doi: 10.1271/bbb.100138. Epub 2010 
      Sep 7.