PMID- 20835611
OWN - NLM
STAT- MEDLINE
DCOM- 20110314
LR  - 20220311
IS  - 1678-8060 (Electronic)
IS  - 0074-0276 (Linking)
VI  - 105
IP  - 5
DP  - 2010 Aug
TI  - Polymorphisms IL10-819 and TLR-2 are potentially associated with sepsis in 
      Brazilian patients.
PG  - 649-56
LID - S0074-02762010000500008 [pii]
AB  - Genetic variation in immune response is probably involved in the progression of 
      sepsis and mortality in septic patients. However, findings in the literature are 
      sometimes conflicting or their significance is uncertain. Thus, we investigated 
      the possible association between 12 polymorphisms located in the interleukin-6 
      (IL6), IL10, TLR-2, Toll-like receptor-4 (TLR-4), tumor necrosis factor-alpha and 
      tumor necrosis factor-beta (lymphotoxin alpha--LTA) genes and sepsis. Critically ill 
      patients classified with sepsis, severe sepsis and septic shock and 207 healthy 
      volunteers were analyzed and genotyped. Seven of the nine polymorphisms showed 
      similar distributions in allele frequencies between patients and controls. 
      Interestingly, our data suggest that the IL10-819 and TLR-2 polymorphisms may be 
      potential predictors of sepsis.
FAU - Carregaro, Fernanda
AU  - Carregaro F
AD  - Departamento de Analises Clinicas, Faculdade de Ciencias Farmaceuticas de 
      Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brasil.
FAU - Carta, Adriana
AU  - Carta A
FAU - Cordeiro, Jose Antonio
AU  - Cordeiro JA
FAU - Lobo, Suzana M
AU  - Lobo SM
FAU - Silva, Eloiza H Tajara da
AU  - Silva EH
FAU - Leopoldino, Andreia M
AU  - Leopoldino AM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Brazil
TA  - Mem Inst Oswaldo Cruz
JT  - Memorias do Instituto Oswaldo Cruz
JID - 7502619
RN  - 0 (Cytokines)
RN  - 0 (Toll-Like Receptors)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Brazil
MH  - Case-Control Studies
MH  - Cytokines/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic/*genetics
MH  - Sepsis/*genetics/mortality
MH  - Severity of Illness Index
MH  - Toll-Like Receptors/*genetics
MH  - Young Adult
EDAT- 2010/09/14 06:00
MHDA- 2011/03/15 06:00
CRDT- 2010/09/14 06:00
PHST- 2009/11/09 00:00 [received]
PHST- 2010/05/12 00:00 [accepted]
PHST- 2010/09/14 06:00 [entrez]
PHST- 2010/09/14 06:00 [pubmed]
PHST- 2011/03/15 06:00 [medline]
AID - S0074-02762010000500008 [pii]
AID - 10.1590/s0074-02762010000500008 [doi]
PST - ppublish
SO  - Mem Inst Oswaldo Cruz. 2010 Aug;105(5):649-56. doi: 
      10.1590/s0074-02762010000500008.