PMID- 20836507
OWN - NLM
STAT- MEDLINE
DCOM- 20110118
LR  - 20131121
IS  - 1520-5207 (Electronic)
IS  - 1520-5207 (Linking)
VI  - 114
IP  - 39
DP  - 2010 Oct 7
TI  - Modulated photophysics of an ESIPT probe 1-hydroxy-2-naphthaldehyde within 
      motionally restricted environments of liposome membranes having varying surface 
      charges.
PG  - 12528-40
LID - 10.1021/jp1048138 [doi]
AB  - The present work demonstrates the modulation of excited state intramolecular 
      proton transfer (ESIPT) emission of 1-hydroxy-2-naphthaldehyde (HN12) upon its 
      interaction with the liposomal vesicles/bilayer of 
      dimyristoyl-l-alpha-phosphatidylcholine (DMPC) and 
      dimyristoyl-l-alpha-phosphatidylglycerol (DMPG) and its subsequent implementation as 
      an efficient molecular reporter for probing of microheterogeneous environments of 
      lipid-bilayer system. Modifications on the emission profile of HN12 in terms of 
      remarkable emission intensity enhancement coupled with a hypsochromic shift 
      induced by the presence of DMPC and DMPG membranes have been interpreted to be 
      vivid manifestations of the interactions between the two partners. Steady-state 
      anisotropy, red-edge excitation shift (REES), and time-resolved fluorescence 
      measurements have been fruitfully exploited to complement other experimental 
      findings. Probable binding site of HN12 in the lipid-bilayers has been assessed 
      on the basis of intertwining the results of fluorescence quenching with other 
      experimental results and is further substantiated from docking studies.
FAU - Paul, Bijan Kumar
AU  - Paul BK
AD  - Department of Chemistry, University of Calcutta, 92 A. P. C. Road, 
      Calcutta-700009, India.
FAU - Guchhait, Nikhil
AU  - Guchhait N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Phys Chem B
JT  - The journal of physical chemistry. B
JID - 101157530
RN  - 0 (1-hydroxy-2-naphthaldehyde)
RN  - 0 (Lipid Bilayers)
RN  - 0 (Liposomes)
RN  - 0 (Naphthols)
RN  - 0 (Phosphatidylglycerols)
RN  - 0 (Protons)
RN  - U86ZGC74V5 (Dimyristoylphosphatidylcholine)
SB  - IM
MH  - Binding Sites
MH  - Computer Simulation
MH  - Dimyristoylphosphatidylcholine/chemistry
MH  - Lipid Bilayers/*chemistry
MH  - Liposomes/*chemistry
MH  - Naphthols/*chemistry
MH  - Phosphatidylglycerols/chemistry
MH  - *Protons
MH  - Spectrometry, Fluorescence
EDAT- 2010/09/15 06:00
MHDA- 2011/01/19 06:00
CRDT- 2010/09/15 06:00
PHST- 2010/09/15 06:00 [entrez]
PHST- 2010/09/15 06:00 [pubmed]
PHST- 2011/01/19 06:00 [medline]
AID - 10.1021/jp1048138 [doi]
PST - ppublish
SO  - J Phys Chem B. 2010 Oct 7;114(39):12528-40. doi: 10.1021/jp1048138.