PMID- 20837332
OWN - NLM
STAT- MEDLINE
DCOM- 20110127
LR  - 20100914
IS  - 1532-1924 (Electronic)
IS  - 1521-6926 (Linking)
VI  - 23
IP  - 2
DP  - 2010 Jun
TI  - Alternative donors hematopoietic stem cells transplantation for adults with acute 
      myeloid leukemia: Umbilical cord blood or haploidentical donors?
PG  - 207-16
LID - 10.1016/j.beha.2010.06.002 [doi]
AB  - Use of allogeneic transplantation for patients with acute myeloid leukemia (AML) 
      depends mainly on the risk of the disease, and HLA matched donor availability. In 
      patients with high-risk leukemia, in the absence of a HLA (human leukocyte 
      antigen) matched donor, alternative donors such as unrelated umbilical cord blood 
      (UCB) or haploidentical donor (haplo) have been currently used. Both strategies 
      have important advantages such as shorter time to transplant, which is 
      particularly relevant to patients requiring urgent transplantation, and tolerance 
      of HLA mismatched graft that make possible that a donor can be found for 
      virtually all patients. However, in spite of higher incidence of graft failure in 
      UCB transplatation recipients and higher relapse incidence after haplo 
      transplants, final outcomes seem to be comparable with HLA matched unrelated 
      hematopoietic stem cell transplantation (bone marrow or peripheral blood). 
      Therefore, the complexity of choosing the best alternative donor will depend on 
      urgency of the transplantation, status and risk of the disease, donor criteria 
      and center experience. Here we review the current status of UCBT and haplo 
      transplants to treat adults with high-risk acute myeloid leukemia and we discuss 
      the main issues associated with the use of both hematopoietic stem cell 
      transplant approaches.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Ruggeri, Annalisa
AU  - Ruggeri A
AD  - Hopital Saint Louis, Universite de Paris, France.
FAU - Ciceri, Fabio
AU  - Ciceri F
FAU - Gluckman, Eliane
AU  - Gluckman E
FAU - Labopin, Myriam
AU  - Labopin M
FAU - Rocha, Vanderson
AU  - Rocha V
CN  - Eurocord and Acute Leukemia Working Party of the European Blood and Marrow 
      Transplant Group
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Best Pract Res Clin Haematol
JT  - Best practice & research. Clinical haematology
JID - 101120659
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Cord Blood Stem Cell Transplantation/*methods
MH  - Female
MH  - Graft vs Host Disease/prevention & control
MH  - *HLA Antigens
MH  - Hematopoietic Stem Cell Transplantation/*methods
MH  - *Histocompatibility
MH  - Humans
MH  - Leukemia, Myeloid, Acute/*therapy
MH  - Male
MH  - Peripheral Blood Stem Cell Transplantation/*methods
MH  - Risk Factors
MH  - *Tissue Donors
MH  - Transplantation, Homologous
EDAT- 2010/09/15 06:00
MHDA- 2011/01/29 06:00
CRDT- 2010/09/15 06:00
PHST- 2010/09/15 06:00 [entrez]
PHST- 2010/09/15 06:00 [pubmed]
PHST- 2011/01/29 06:00 [medline]
AID - S1521-6926(10)00032-0 [pii]
AID - 10.1016/j.beha.2010.06.002 [doi]
PST - ppublish
SO  - Best Pract Res Clin Haematol. 2010 Jun;23(2):207-16. doi: 
      10.1016/j.beha.2010.06.002.