PMID- 2083991
OWN - NLM
STAT- MEDLINE
DCOM- 19910515
LR  - 20190510
IS  - 0300-5771 (Print)
IS  - 0300-5771 (Linking)
VI  - 19
IP  - 4
DP  - 1990 Dec
TI  - The effective case management of childhood diarrhoea with oral rehydration 
      therapy in the Kingdom of Lesotho.
PG  - 1066-71
AB  - In Lesotho prior to 1986, diarrhoea was the leading cause of hospital mortality 
      in children less than 5 years of age. At the Queen Elizabeth II Hospital, 
      diarrhoea-related admissions as a proportion of all admissions in children less 
      than 5 years of age declined from 23% in the year prior to the opening of the 
      Oral Rehydration Therapy Unit (ORTU) to 13% in the first nine months of 1987 (p 
      less than 0.05). In addition, the case-fatality ratio of children treated in the 
      ORTU declined from 1.4% in the first quarter of 1986 to zero in the second and 
      third quarters of 1987 (p less than 0.05). In a case-control study conducted to 
      identify reasons for children failing ORTU treatment, factors associated with an 
      increased risk of hospitalization included male gender (odds ratio [OR] = 4.9; 
      95% confidence limits [CL] = 2.0, 11.9), fever greater than or equal to 38.5 
      degrees C (OR = 2.0; CL = 1.2, 3.3), undernutrition (OR = 3.2; CL = 1.1, 9.4), 
      and moderate dehydration (OR = 2.3; CL = 1.2, 4.4) or severe dehydration. (OR = 
      12.1; CL = 3.8, 38.5). Breastfed children less than 2 years of age were at 
      decreased risk of hospitalization (OR = 0.4; CL = 0.2, 0.7). At this major 
      hospital in Lesotho, the standardization of outpatient treatment for diarrhoea 
      with oral rehydration salts (ORS) in the context of an ORTU resulted in a marked 
      decrease in diarrhoea-associated hospitalization and deaths in children less than 
      5 years of age.
FAU - Hatch, D L
AU  - Hatch DL
AD  - Technical Support Division, Centers for Disease Control, Atlanta, GA 30333.
FAU - Vreuls, R C
AU  - Vreuls RC
FAU - Toole, M J
AU  - Toole MJ
FAU - Moteetee, M M
AU  - Moteetee MM
FAU - Monoang, I
AU  - Monoang I
FAU - Ngatane, C M
AU  - Ngatane CM
FAU - Gittelman, D M
AU  - Gittelman DM
FAU - Waldman, R J
AU  - Waldman RJ
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Epidemiol
JT  - International journal of epidemiology
JID - 7802871
SB  - IM
MH  - Case-Control Studies
MH  - Child, Preschool
MH  - Dehydration/therapy
MH  - Diarrhea/epidemiology/*therapy
MH  - Female
MH  - *Fluid Therapy
MH  - Humans
MH  - Infant
MH  - Lesotho/epidemiology
MH  - Male
MH  - Nutrition Disorders
MH  - Outpatient Clinics, Hospital
MH  - Patient Admission/statistics & numerical data
MH  - Sex Factors
OID - PIP: 067611
OID - POP: 00205094
OTO - PIP
OT  - Africa
OT  - Africa South Of The Sahara
OT  - *Age Factors
OT  - Biology
OT  - *Breast Feeding--beneficial effects
OT  - *Case Control Studies
OT  - *Child Mortality
OT  - *Data Analysis
OT  - Demographic Factors
OT  - Developing Countries
OT  - Diarrhea
OT  - *Diarrhea, Infantile
OT  - Diseases
OT  - English Speaking Africa
OT  - *Evaluation
OT  - Health
OT  - Infant Nutrition
OT  - Lesotho
OT  - *Malnutrition
OT  - Mortality
OT  - Nutrition
OT  - Nutrition Disorders
OT  - *Oral Rehydration
OT  - Population
OT  - Population Characteristics
OT  - Population Dynamics
OT  - Research Methodology
OT  - *Risk Factors
OT  - *Sex Factors
OT  - Southern Africa
OT  - Studies
OT  - Treatment
GN  - PIP: TJ: INTERNATIONAL JOURNAL OF EPIDEMIOLOGY.
EDAT- 1990/12/01 00:00
MHDA- 1990/12/01 00:01
CRDT- 1990/12/01 00:00
PHST- 1990/12/01 00:00 [pubmed]
PHST- 1990/12/01 00:01 [medline]
PHST- 1990/12/01 00:00 [entrez]
AID - 10.1093/ije/19.4.1066 [doi]
PST - ppublish
SO  - Int J Epidemiol. 1990 Dec;19(4):1066-71. doi: 10.1093/ije/19.4.1066.