PMID- 20842443
OWN - NLM
STAT- MEDLINE
DCOM- 20110523
LR  - 20221207
IS  - 1573-4978 (Electronic)
IS  - 0301-4851 (Linking)
VI  - 38
IP  - 3
DP  - 2011 Mar
TI  - Association between HLA-DRB1, HLA-DRQB1 alleles, and CD4(+)CD28(null) T cells in 
      a Chinese population with coronary heart disease.
PG  - 1675-9
LID - 10.1007/s11033-010-0279-8 [doi]
AB  - CD4(+)CD28(null) T cells are present in increased numbers in the peripheral blood 
      of patients with acute coronary syndrome. However, the triggers of expansion of 
      these cells are unclear. Susceptibility to coronary heart disease (CHD) is 
      strongly associated with alleles of human leukocyte antigen (HLA), but it is not 
      equally strong in different human populations. The objective of the study was to 
      investigate association between CD4(+)CD28(null) T cells and HLA-DRB1 alleles. 
      The HLA alleles were determined by polymerase chain reaction with 
      sequence-specific primers (PCR-SSP) method, in a group of CHD patients and 
      control subjects from the same area. The number of CD4(+)CD28(null) T cells was 
      measured using the flow cytometry technique. The HLA-DRB1*01 (RR = 4.705, P < 
      0.005) and DRB1*04 (RR = 3.554, P < 0.005) alleles showed the strongest 
      association with CHD in the Chinese population, and increased numbers of 
      CD4(+)CD28(null) T cells were found in association with HLA-DRB1*04 (17.1%) and 
      DRB*01 (12.9%), while decreased numbers of CD4(+)CD28(null) T cells were present 
      in subjects with DRB1*15 (0.8%). CHD in Chinese population is strongly associated 
      with HLA-DRB1*01 and DRB1*04 haplotypes, and formation of CD4(+)CD28(null) T 
      cells was related to HLA-DRB1*01, DRB1*04, and DRB1*15 alleles.
FAU - Sun, Wenjie
AU  - Sun W
AD  - Department of Laboratory Medicine, The Second Affiliated Hospital of Harbin 
      Medical University, Harbin 150086, People's Republic of China.
FAU - Cui, Ying
AU  - Cui Y
FAU - Zhen, Lihui
AU  - Zhen L
FAU - Huang, Lijuan
AU  - Huang L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100915
PL  - Netherlands
TA  - Mol Biol Rep
JT  - Molecular biology reports
JID - 0403234
RN  - 0 (CD28 Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Acute Coronary Syndrome/genetics/immunology
MH  - Alleles
MH  - Asian People/*genetics
MH  - CD28 Antigens/*genetics
MH  - CD4 Lymphocyte Count
MH  - CD4-Positive T-Lymphocytes/*immunology
MH  - Case-Control Studies
MH  - Coronary Disease/*genetics/immunology
MH  - Flow Cytometry
MH  - *Genetic Predisposition to Disease
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Humans
EDAT- 2010/09/16 06:00
MHDA- 2011/05/24 06:00
CRDT- 2010/09/16 06:00
PHST- 2010/02/02 00:00 [received]
PHST- 2010/09/02 00:00 [accepted]
PHST- 2010/09/16 06:00 [entrez]
PHST- 2010/09/16 06:00 [pubmed]
PHST- 2011/05/24 06:00 [medline]
AID - 10.1007/s11033-010-0279-8 [doi]
PST - ppublish
SO  - Mol Biol Rep. 2011 Mar;38(3):1675-9. doi: 10.1007/s11033-010-0279-8. Epub 2010 
      Sep 15.