PMID- 20842519
OWN - NLM
STAT- MEDLINE
DCOM- 20110218
LR  - 20220409
IS  - 1573-2622 (Electronic)
IS  - 0012-4486 (Print)
IS  - 0012-4486 (Linking)
VI  - 121
IP  - 3
DP  - 2010 Dec
TI  - Efficacy of topical dorzolamide for treatment of cystic macular lesions in a 
      patient with enhanced S-cone syndrome.
PG  - 231-40
LID - 10.1007/s10633-010-9247-9 [doi]
AB  - The purpose of this study was to evaluate the efficacy of topical dorzolamide 2% 
      eye drops on macular function and thickness in a case of enhanced S-cone syndrome 
      (ESCS). A 24-year-old Asian man with enhanced S-cone syndrome treated with 
      topical dorzolamide in the left eye participated in the study. Examinations 
      performed before and during treatment were included visual acuity (VA), contrast 
      sensitivity measured with briefly presented grating targets (grating CS) and the 
      Pelli-Robson chart (P-R CS), microperimetry (MP), and spectral-domain optical 
      coherence tomography (SD-OCT). Following 4 months of treatment, the mean 
      thickness of the central 1-mm foveal subfield of the left eye, as measured by 
      SD-OCT, decreased from 551 to 242 mum. Mean MP sensitivity within the central 12 
      degrees (28 points) increased from 9.4 dB at baseline to 11.2 dB. Although 
      Pelli-Robson contrast sensitivity improved only minimally in the left eye, 
      grating contrast sensitivity improved by more than a factor of two. Mean log MAR 
      VA was 0.22 OD and 1.00 OS (at baseline), which improved to 0.10 OD and 0.66 OS 
      after 4 months of treatment. The results indicate that in our patient with 
      enhanced S-cone syndrome, treatment with topical dorzolamide was effective in 
      improving macular thickness, VA, microperimetry sensitivity, and grating contrast 
      sensitivity. These measures of retinal structure and function are sensitive tools 
      for evaluating the effects of treatment in enhanced S-cone syndrome patients with 
      cystoid macular edema. Further investigation is warranted to assess the 
      relationships among visual performance for daily activities, visual sensitivity, 
      and macular thickness.
FAU - Genead, Mohamed A
AU  - Genead MA
AD  - Department of Ophthalmology and Visual Sciences (MC 648), University of Illinois 
      at Chicago, Room 3.85, Eye and Ear Infirmary, 1855 W Taylor Street, Chicago, IL 
      60612-7234, USA.
FAU - Fishman, Gerald A
AU  - Fishman GA
FAU - McAnany, J Jason
AU  - McAnany JJ
LA  - eng
GR  - P30 EY001792/EY/NEI NIH HHS/United States
GR  - R00 EY019510/EY/NEI NIH HHS/United States
GR  - EY019510/EY/NEI NIH HHS/United States
GR  - EYO1792/PHS HHS/United States
GR  - K99 EY019510/EY/NEI NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20100915
PL  - Netherlands
TA  - Doc Ophthalmol
JT  - Documenta ophthalmologica. Advances in ophthalmology
JID - 0370667
RN  - 0 (Carbonic Anhydrase Inhibitors)
RN  - 0 (Sulfonamides)
RN  - 0 (Thiophenes)
RN  - 9JDX055TW1 (dorzolamide)
SB  - IM
MH  - Administration, Topical
MH  - Carbonic Anhydrase Inhibitors/*administration & dosage
MH  - Contrast Sensitivity
MH  - Humans
MH  - Macular Edema/*complications/*drug therapy/physiopathology
MH  - Male
MH  - *Retinal Cone Photoreceptor Cells
MH  - Retinal Diseases/complications/*diagnosis/*drug therapy/physiopathology
MH  - Sulfonamides/*administration & dosage
MH  - Syndrome
MH  - Thiophenes/*administration & dosage
MH  - Tomography, Optical Coherence/methods
MH  - Treatment Outcome
MH  - Visual Acuity
MH  - Visual Field Tests
MH  - Young Adult
PMC - PMC3688632
MID - NIHMS481804
EDAT- 2010/09/16 06:00
MHDA- 2011/02/22 06:00
PMCR- 2013/06/20
CRDT- 2010/09/16 06:00
PHST- 2010/07/08 00:00 [received]
PHST- 2010/08/20 00:00 [accepted]
PHST- 2010/09/16 06:00 [entrez]
PHST- 2010/09/16 06:00 [pubmed]
PHST- 2011/02/22 06:00 [medline]
PHST- 2013/06/20 00:00 [pmc-release]
AID - 10.1007/s10633-010-9247-9 [doi]
PST - ppublish
SO  - Doc Ophthalmol. 2010 Dec;121(3):231-40. doi: 10.1007/s10633-010-9247-9. Epub 2010 
      Sep 15.