PMID- 20843135
OWN - NLM
STAT- MEDLINE
DCOM- 20110329
LR  - 20170308
IS  - 2476-762X (Electronic)
IS  - 1513-7368 (Linking)
VI  - 11
IP  - 2
DP  - 2010
TI  - Cisplatin combination chemotherapy induces oxidative stress in advance non small 
      cell lung cancer patients.
PG  - 465-71
AB  - BACKGROUND: This study determine oxidative stress and survival prospectively in 
      advanced stage non small cell lung cancer (NSCLC) patients following cisplatin 
      based combination chemotherapy. MATERIALS AND METHODS: The oxidative stress 
      levels (LPO, NO, GSH and SOD) of 144 control subjects and 203 advanced stage 
      (IIIA/IIIB/IV) newly diagnosed NSCLC patients were assessed at pre-treatment (day 
      '0'), and after the 3rd and 6th cycles of chemotherapy. Groups were compared by 
      repeated measures ANOVA while comparison of survival curves was conduced by 
      Kaplan-Meier methods. RESULTS: The pre-treatment mean levels of LPO and NO in 
      patients were significantly (P<0.01) higher while GSH and SOD were significantly 
      (P<0.01) lower as compared to control. The oxidative stress was elevated more 
      significantly (P<0.01) after the chemotherapy and was more evident in higher 
      stage than lower stage patients. The two year overall survival (%) of stage IV 
      patients was significantly lower (P<0.05) as compared to stage III A and III B. 
      The proportional mortality was also maximal in stage IV patients (37.0%) followed 
      by stage III B (31.7%) and III A (20.0%). CONCLUSION: Cisplatin based combination 
      chemotherapy induces oxidative stress in NSCLC patients.
FAU - Srivastava, Anand Narain
AU  - Srivastava AN
AD  - Department of Pathology, Era's Lucknow Medical College and Hospital, 
      Sarfarazganj, Moosa bagh, Picnic spot, India. inansrivastava@gmail.com
FAU - Gupta, Abhilasha
AU  - Gupta A
FAU - Srivastava, Shruti
AU  - Srivastava S
FAU - Natu, S M
AU  - Natu SM
FAU - Mittal, Balraj
AU  - Mittal B
FAU - Negi, M P S
AU  - Negi MP
FAU - Prasad, Rajendra
AU  - Prasad R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Thailand
TA  - Asian Pac J Cancer Prev
JT  - Asian Pacific journal of cancer prevention : APJCP
JID - 101130625
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 6PLQ3CP4P3 (Etoposide)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - Q20Q21Q62J (Cisplatin)
SB  - IM
MH  - Adenocarcinoma/*drug therapy/pathology
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
MH  - Carcinoma, Large Cell/*drug therapy/pathology
MH  - Carcinoma, Non-Small-Cell Lung/*drug therapy/pathology
MH  - Carcinoma, Squamous Cell/*drug therapy/pathology
MH  - Case-Control Studies
MH  - Cisplatin/administration & dosage
MH  - Etoposide/administration & dosage
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Lipid Peroxidation/drug effects
MH  - Lung Neoplasms/*drug therapy/pathology
MH  - Male
MH  - Middle Aged
MH  - Nitric Oxide/metabolism
MH  - Oxidative Stress/*drug effects
MH  - Superoxide Dismutase/metabolism
MH  - Survival Rate
MH  - Treatment Outcome
EDAT- 2010/09/17 06:00
MHDA- 2011/03/30 06:00
CRDT- 2010/09/17 06:00
PHST- 2010/09/17 06:00 [entrez]
PHST- 2010/09/17 06:00 [pubmed]
PHST- 2011/03/30 06:00 [medline]
PST - ppublish
SO  - Asian Pac J Cancer Prev. 2010;11(2):465-71.