PMID- 20844040
OWN - NLM
STAT- MEDLINE
DCOM- 20101220
LR  - 20220316
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Print)
IS  - 0022-538X (Linking)
VI  - 84
IP  - 23
DP  - 2010 Dec
TI  - Herpesviruses and chromosomal integration.
PG  - 12100-9
LID - 10.1128/JVI.01169-10 [doi]
AB  - Herpesviruses are members of a diverse family of viruses that colonize all 
      vertebrates from fish to mammals. Although more than one hundred herpesviruses 
      exist, all are nearly identical architecturally, with a genome consisting of a 
      linear double-stranded DNA molecule (100 to 225 kbp) protected by an icosahedral 
      capsid made up of 162 hollow-centered capsomeres, a tegument surrounding the 
      nucleocapsid, and a viral envelope derived from host membranes. Upon infection, 
      the linear viral DNA is delivered to the nucleus, where it circularizes to form 
      the viral episome. Depending on several factors, the viral cycle can proceed 
      either to a productive infection or to a state of latency. In either case, the 
      viral genetic information is maintained as extrachromosomal circular DNA. 
      Interestingly, however, certain oncogenic herpesviruses such as Marek's disease 
      virus and Epstein-Barr virus can be found integrated at low frequencies in the 
      host's chromosomes. These findings have mostly been viewed as anecdotal and 
      considered exceptions rather than properties of herpesviruses. In recent years, 
      the consistent and rather frequent detection (in approximately 1% of the human 
      population) of human herpesvirus 6 (HHV-6) viral DNA integrated into human 
      chromosomes has spurred renewed interest in our understanding of how these 
      viruses infect, replicate, and propagate themselves. In this review, we provide a 
      historical perspective on chromosomal integration by herpesviruses and present 
      the current state of knowledge on integration by HHV-6 with the possible clinical 
      implications associated with viral integration.
FAU - Morissette, Guillaume
AU  - Morissette G
AD  - Centre de Recherche en Rhumatologie et Immunologie, Centre Hospitalier 
      Universitaire de Quebec, Quebec, Canada.
FAU - Flamand, Louis
AU  - Flamand L
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100915
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
SB  - IM
MH  - Animals
MH  - Chickens
MH  - Chromosomes, Human/genetics/*virology
MH  - Genome, Viral/genetics/physiology
MH  - Herpesvirus 2, Gallid/*genetics/physiology
MH  - Herpesvirus 4, Human/*genetics/physiology
MH  - Herpesvirus 6, Human/*genetics/*physiology
MH  - Humans
MH  - *Models, Molecular
MH  - Virus Integration/genetics/*physiology
PMC - PMC2976420
EDAT- 2010/09/17 06:00
MHDA- 2010/12/21 06:00
PMCR- 2011/06/01
CRDT- 2010/09/17 06:00
PHST- 2010/09/17 06:00 [entrez]
PHST- 2010/09/17 06:00 [pubmed]
PHST- 2010/12/21 06:00 [medline]
PHST- 2011/06/01 00:00 [pmc-release]
AID - JVI.01169-10 [pii]
AID - 1169-10 [pii]
AID - 10.1128/JVI.01169-10 [doi]
PST - ppublish
SO  - J Virol. 2010 Dec;84(23):12100-9. doi: 10.1128/JVI.01169-10. Epub 2010 Sep 15.