PMID- 20844677
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 0975-1599 (Electronic)
IS  - 0974-9233 (Print)
IS  - 0974-9233 (Linking)
VI  - 17
IP  - 3
DP  - 2010 Jul
TI  - Molecular pathology of retinoblastoma.
PG  - 217-23
LID - 10.4103/0974-9233.65498 [doi]
AB  - Retinoblastoma (RB) is an embryonic neoplasm of retinal origin. For many years, 
      scientists have sought the fundamental origins of tumorigenesis, with the 
      ultimate hope of discovering a cure. Indeed, these efforts have led to a 
      significant understanding that multiple molecular and genetic aberrations, such 
      as uncontrolled proliferation and the inhibition of apoptosis that contribute to 
      the canonical characteristics of tumor biology. Despite these advances, a 
      thorough understanding, such as the precise cells, which are the targets of 
      neoplastic transformation, especially in solid tumors, is currently lacking. The 
      focus of this review is to emphasize the molecular defects involved in the RB 
      tumor progression and mechanisms associated with inhibition of tumor cell 
      apoptotic processes. This review also discusses the importance of target 
      molecules characterization and their potential therapeutic or prognostic use in 
      RB disease.
FAU - Kandalam, Mallikarjuna
AU  - Kandalam M
AD  - Department of Ocular Pathology, Vision Research Foundation, Sankara Nethralaya, 
      Chennai, India.
FAU - Mitra, Moutushy
AU  - Mitra M
FAU - Subramanian, Krishnakumar
AU  - Subramanian K
FAU - Biswas, Jyotirmay
AU  - Biswas J
LA  - eng
PT  - Journal Article
PL  - India
TA  - Middle East Afr J Ophthalmol
JT  - Middle East African journal of ophthalmology
JID - 101521797
PMC - PMC2934713
OTO - NOTNLM
OT  - Pathology
OT  - Proteomics
OT  - Retinoblastoma
OT  - Target Therapy
COIS- Conflict of Interest: None declared.
EDAT- 2010/09/17 06:00
MHDA- 2010/09/17 06:01
PMCR- 2010/07/01
CRDT- 2010/09/17 06:00
PHST- 2010/09/17 06:00 [entrez]
PHST- 2010/09/17 06:00 [pubmed]
PHST- 2010/09/17 06:01 [medline]
PHST- 2010/07/01 00:00 [pmc-release]
AID - MEAJO-17-217 [pii]
AID - 10.4103/0974-9233.65498 [doi]
PST - ppublish
SO  - Middle East Afr J Ophthalmol. 2010 Jul;17(3):217-23. doi: 
      10.4103/0974-9233.65498.