PMID- 20846025
OWN - NLM
STAT- MEDLINE
DCOM- 20110202
LR  - 20131121
IS  - 1537-6524 (Electronic)
IS  - 1537-6516 (Linking)
VI  - 20
IP  - 9
DP  - 2010 Nov
TI  - Effect of Piper betle on cardiac function, marker enzymes, and oxidative stress 
      in isoproterenol-induced cardiotoxicity in rats.
PG  - 564-71
LID - 10.3109/15376516.2010.514962 [doi]
AB  - The present study was designed to investigate the cardioprotective potential of 
      Piper betle (P. betle) against isoproterenol (ISP)-induced myocardial infarction 
      in rats. Rats were randomly divided into eight groups viz. control, ISP, P. betle 
      (75, 150, and 300 mg/kg) and P. betle (75, 150, and 300 mg/kg) + ISP treated 
      group. P. betle leaf extract (75, 150, or 300 mg/kg) or saline was orally 
      administered for 30 days. ISP (85 mg/kg, s.c.) was administered at an interval of 
      24 h on the 28(th) and 29(th) day and on day 30 the functional and biochemical 
      parameters were measured. ISP administration showed a significant decrease in 
      systolic, diastolic, mean arterial pressure (SAP, DAP, MAP), heart rate (HR), 
      contractility (+LVdP/dt), and relaxation (-LVdP/dt) and increased left 
      ventricular end-diastolic pressure (LVEDP). ISP also caused significant decrease 
      in myocardial antioxidants; superoxide dismutase (SOD), catalase (CAT), 
      glutathione peroxidase (GPx), reduced glutathione (GSH), and myocyte injury 
      marker enzymes; creatine phosphokinase-MB (CK-MB) isoenzyme and lactate 
      dehydrogenase (LDH) along with enhanced lipid peroxidation; thiobarbituric acid 
      reacting species (TBARS) in heart. Pre-treatment with P. betle favorably 
      modulated hemodynamic (SAP, DAP, and MAP) and ventricular function parameters 
      (-LVdP/dt and LVEDP). P. betle pre-treatment also restored SOD, CAT, GSH, and 
      GPx, reduced the leakage of CK-MB isoenzyme and LDH along with decreased lipid 
      peroxidation in the heart. Taken together, the biochemical and functional 
      parameters indicate that P. betle 150 and 300 mg/kg has a significant 
      cardioprotective effect against ISP-induced myocardial infarction. Results of the 
      present study suggest the cardioprotective potential of P. betle.
FAU - Arya, Dharamvir Singh
AU  - Arya DS
AD  - Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, 
      India.
FAU - Arora, Sachin
AU  - Arora S
FAU - Malik, Salma
AU  - Malik S
FAU - Nepal, Saroj
AU  - Nepal S
FAU - Kumari, Santosh
AU  - Kumari S
FAU - Ojha, Shreesh
AU  - Ojha S
LA  - eng
PT  - Journal Article
DEP - 20100916
PL  - England
TA  - Toxicol Mech Methods
JT  - Toxicology mechanisms and methods
JID - 101134521
RN  - 0 (Cardiotonic Agents)
RN  - 0 (Cardiotoxins)
RN  - 0 (Plant Extracts)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - GAN16C9B8O (Glutathione)
RN  - L628TT009W (Isoproterenol)
SB  - IM
MH  - Animals
MH  - Blood Pressure/drug effects
MH  - Cardiotonic Agents/*pharmacology
MH  - Cardiotoxins/toxicity
MH  - Glutathione/metabolism
MH  - Heart/*drug effects
MH  - Isoproterenol/toxicity
MH  - Male
MH  - Myocardium/enzymology/*metabolism
MH  - Oxidative Stress/drug effects
MH  - *Piper betle
MH  - Plant Extracts/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Thiobarbituric Acid Reactive Substances/metabolism
EDAT- 2010/09/18 06:00
MHDA- 2011/02/03 06:00
CRDT- 2010/09/18 06:00
PHST- 2010/09/18 06:00 [entrez]
PHST- 2010/09/18 06:00 [pubmed]
PHST- 2011/02/03 06:00 [medline]
AID - 10.3109/15376516.2010.514962 [doi]
PST - ppublish
SO  - Toxicol Mech Methods. 2010 Nov;20(9):564-71. doi: 10.3109/15376516.2010.514962. 
      Epub 2010 Sep 16.