PMID- 20846914
OWN - NLM
STAT- MEDLINE
DCOM- 20110124
LR  - 20151119
IS  - 1873-376X (Electronic)
IS  - 1570-0232 (Linking)
VI  - 878
IP  - 28
DP  - 2010 Oct 15
TI  - Free fatty acid metabolic profile and biomarkers of isolated post-challenge 
      diabetes and type 2 diabetes mellitus based on GC-MS and multivariate statistical 
      analysis.
PG  - 2817-25
LID - 10.1016/j.jchromb.2010.08.035 [doi]
AB  - Isolated post-challenge diabetes (IPD, 2h-PG >/=11.1mmol/L and FPG <7.0mmol/L) is 
      often ignored in screening for diabetes by fasting plasma glucose (FPG) levels. 
      The aim of this study was to investigate the metabolic profiles of serum free 
      fatty acids (FFAs) and to identify biomarkers that can be used to distinguish 
      patients with IPD from those with type 2 diabetes mellitus (T2DM) or healthy 
      control individuals. FFA profiles of the subjects were investigated using gas 
      chromatography-mass spectrometry (GC-MS). Principal component analysis (PCA) and 
      partial least squares-discriminant analysis (PLS-DA) were used for classification 
      and prediction among the three groups. The predictive correct rates were 92.86% 
      for IPD and healthy control individuals and 90.70% for T2DM and healthy control 
      individuals, indicating that PLS-DA could satisfactorily distinguish IPD 
      individuals from healthy controls and those with T2DM. Finally, palmitic acid, 
      stearic acid, oleic acid, linoleic acid and alpha-linolenic acid were identified as 
      potential biomarkers for distinguishing IPD from healthy control and T2DM 
      individuals. These potential biomarkers might be helpful for diagnosis and 
      characterization of diabetes.
CI  - Copyright (c) 2010 Elsevier B.V. All rights reserved.
FAU - Liu, Liyan
AU  - Liu L
AD  - Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical 
      University, 157 Baojian Road, Nangang District, Harbin 150086, PR China.
FAU - Li, Ying
AU  - Li Y
FAU - Guan, Chunmei
AU  - Guan C
FAU - Li, Kang
AU  - Li K
FAU - Wang, Cheng
AU  - Wang C
FAU - Feng, Rennan
AU  - Feng R
FAU - Sun, Changhao
AU  - Sun C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100916
PL  - Netherlands
TA  - J Chromatogr B Analyt Technol Biomed Life Sci
JT  - Journal of chromatography. B, Analytical technologies in the biomedical and life 
      sciences
JID - 101139554
RN  - 0 (Biomarkers)
RN  - 0 (Fatty Acids, Nonesterified)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Analysis of Variance
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Fatty Acids, Nonesterified/*blood
MH  - Female
MH  - Gas Chromatography-Mass Spectrometry
MH  - Humans
MH  - Least-Squares Analysis
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Principal Component Analysis
MH  - Reproducibility of Results
EDAT- 2010/09/18 06:00
MHDA- 2011/01/25 06:00
CRDT- 2010/09/18 06:00
PHST- 2010/05/13 00:00 [received]
PHST- 2010/08/09 00:00 [revised]
PHST- 2010/08/24 00:00 [accepted]
PHST- 2010/09/18 06:00 [entrez]
PHST- 2010/09/18 06:00 [pubmed]
PHST- 2011/01/25 06:00 [medline]
AID - S1570-0232(10)00533-7 [pii]
AID - 10.1016/j.jchromb.2010.08.035 [doi]
PST - ppublish
SO  - J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Oct 15;878(28):2817-25. doi: 
      10.1016/j.jchromb.2010.08.035. Epub 2010 Sep 16.