PMID- 20847403
OWN - NLM
STAT- MEDLINE
DCOM- 20110309
LR  - 20220408
IS  - 1875-8908 (Electronic)
IS  - 1387-2877 (Print)
IS  - 1387-2877 (Linking)
VI  - 22
IP  - 2
DP  - 2010
TI  - Aerobic exercise improves cognition for older adults with glucose intolerance, a 
      risk factor for Alzheimer's disease.
PG  - 569-79
LID - 10.3233/JAD-2010-100768 [doi]
AB  - Impaired glucose regulation is a defining characteristic of type 2 diabetes 
      mellitus (T2DM) pathology and has been linked to increased risk of cognitive 
      impairment and dementia. Although the benefits of aerobic exercise for physical 
      health are well-documented, exercise effects on cognition have not been examined 
      for older adults with poor glucose regulation associated with prediabetes and 
      early T2DM. Using a randomized controlled design, twenty-eight adults (57-83 y 
      old) meeting 2-h tolerance test criteria for glucose intolerance completed 6 
      months of aerobic exercise or stretching, which served as the control. The 
      primary cognitive outcomes included measures of executive function (Trails B, 
      Task Switching, Stroop, Self-ordered Pointing Test, and Verbal Fluency). Other 
      outcomes included memory performance (Story Recall, List Learning), measures of 
      cardiorespiratory fitness obtained via maximal-graded exercise treadmill test, 
      glucose disposal during hyperinsulinemic-euglycemic clamp, body fat, and fasting 
      plasma levels of insulin, cortisol, brain-derived neurotrophic factor, 
      insulin-like growth factor-1, amyloid-beta (Abeta40 and Abeta42). Six months of aerobic 
      exercise improved executive function (MANCOVA, p=0.04), cardiorespiratory fitness 
      (MANOVA, p=0.03), and insulin sensitivity (p=0.05). Across all subjects, 6-month 
      changes in cardiorespiratory fitness and insulin sensitivity were positively 
      correlated (p=0.01). For Abeta42, plasma levels tended to decrease for the aerobic 
      group relative to controls (p=0.07). The results of our study using rigorous 
      controlled methodology suggest a cognition-enhancing effect of aerobic exercise 
      for older glucose intolerant adults. Although replication in a larger sample is 
      needed, our findings potentially have important therapeutic implications for a 
      growing number of adults at increased risk of cognitive decline.
FAU - Baker, Laura D
AU  - Baker LD
AD  - Department of Psychiatry and Behavioral Sciences, University of Washington School 
      of Medicine, Seattle, WA, USA. ldbaker@uw.edu
FAU - Frank, Laura L
AU  - Frank LL
FAU - Foster-Schubert, Karen
AU  - Foster-Schubert K
FAU - Green, Pattie S
AU  - Green PS
FAU - Wilkinson, Charles W
AU  - Wilkinson CW
FAU - McTiernan, Anne
AU  - McTiernan A
FAU - Cholerton, Brenna A
AU  - Cholerton BA
FAU - Plymate, Stephen R
AU  - Plymate SR
FAU - Fishel, Mark A
AU  - Fishel MA
FAU - Watson, G Stennis
AU  - Watson GS
FAU - Duncan, Glen E
AU  - Duncan GE
FAU - Mehta, Pankaj D
AU  - Mehta PD
FAU - Craft, Suzanne
AU  - Craft S
LA  - eng
SI  - ClinicalTrials.gov/NCT00220441
GR  - KL2 RR025015/RR/NCRR NIH HHS/United States
GR  - KL2 RR025015-03/RR/NCRR NIH HHS/United States
GR  - UL1 TR000423/TR/NCATS NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - Netherlands
TA  - J Alzheimers Dis
JT  - Journal of Alzheimer's disease : JAD
JID - 9814863
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Aged
MH  - Alzheimer Disease/*etiology
MH  - Amyloid beta-Peptides/blood
MH  - Brain-Derived Neurotrophic Factor/blood
MH  - Cognition Disorders/*etiology/*rehabilitation
MH  - Executive Function/physiology
MH  - *Exercise
MH  - Exercise Therapy/*methods
MH  - Female
MH  - Follow-Up Studies
MH  - Glucose Clamp Technique/methods
MH  - Glucose Intolerance/*complications/rehabilitation
MH  - Heart Rate/physiology
MH  - Humans
MH  - Insulin-Like Growth Factor I/metabolism
MH  - Male
MH  - Memory/physiology
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Oxygen Consumption/physiology
MH  - Risk Factors
PMC - PMC3049111
MID - NIHMS267530
COIS- The authors have no conflict of interest to disclose.
EDAT- 2010/09/18 06:00
MHDA- 2011/03/10 06:00
PMCR- 2011/03/05
CRDT- 2010/09/18 06:00
PHST- 2010/09/18 06:00 [entrez]
PHST- 2010/09/18 06:00 [pubmed]
PHST- 2011/03/10 06:00 [medline]
PHST- 2011/03/05 00:00 [pmc-release]
AID - 04172L5V1413114M [pii]
AID - 10.3233/JAD-2010-100768 [doi]
PST - ppublish
SO  - J Alzheimers Dis. 2010;22(2):569-79. doi: 10.3233/JAD-2010-100768.