PMID- 20847425
OWN - NLM
STAT- MEDLINE
DCOM- 20110309
LR  - 20131121
IS  - 1875-8908 (Electronic)
IS  - 1387-2877 (Linking)
VI  - 22
IP  - 2
DP  - 2010
TI  - Greater default-mode network abnormalities compared to high order visual 
      processing systems in amnestic mild cognitive impairment: an integrated 
      multi-modal MRI study.
PG  - 523-39
LID - 10.3233/JAD-2010-101038 [doi]
AB  - We conducted an integrated multi-modal magnetic resonance imaging (MRI) study 
      based on functional MRI (fMRI) data during a complex but cognitively preserved 
      visual task in 15 amnestic mild cognitive impairment (a-MCI) patients and 15 
      Healthy Elders (HE). Independent Component Analysis of fMRI data identified a 
      functional network containing an Activation Task Related Pattern (ATRP), 
      including regions of the dorsal and ventral visual stream, and a Deactivation 
      Task Related Pattern network (DTRP), with high spatial correspondence with the 
      default-mode network (DMN). Gray matter (GM) volumes of the underlying ATRP and 
      DTRP cortical areas were measured, and probabilistic tractography (based on 
      diffusion MRI) identified fiber pathways within each functional network. For the 
      ATRP network, a-MCI patients exhibited increased fMRI responses in 
      inferior-ventral visual areas, possibly reflecting compensatory activations for 
      more compromised dorsal regions. However, no significant GM or white matter group 
      differences were observed within the ATRP network. For the DTRP/DMN, a-MCI showed 
      deactivation deficits and reduced GM volumes in the posterior 
      cingulate/precuneus, excessive deactivations in the inferior parietal lobe, and 
      less fiber tract integrity in the cingulate bundles. Task performance correlated 
      with DTRP-functionality in the HE group. Besides allowing the identification of 
      functional reorganizations in the cortical network directly processing the 
      task-stimuli, these findings highlight the importance of conducting integrated 
      multi-modal MRI studies in MCI based on spared cognitive domains in order to 
      identify functional abnormalities in critical areas of the DMN and their precise 
      anatomical substrates. These latter findings may reflect early neuroimaging 
      biomarkers in dementia.
FAU - Sala-Llonch, Roser
AU  - Sala-Llonch R
AD  - Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, 
      Hospital Clinic de Barcelona, Catalonia, Spain.
FAU - Bosch, Beatriz
AU  - Bosch B
FAU - Arenaza-Urquijo, Eider M
AU  - Arenaza-Urquijo EM
FAU - Rami, Lorena
AU  - Rami L
FAU - Bargallo, Nuria
AU  - Bargallo N
FAU - Junque, Carme
AU  - Junque C
FAU - Molinuevo, Jose-Luis
AU  - Molinuevo JL
FAU - Bartres-Faz, David
AU  - Bartres-Faz D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Alzheimers Dis
JT  - Journal of Alzheimer's disease : JAD
JID - 9814863
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Amnesia/complications/*pathology
MH  - *Brain Mapping/methods
MH  - Cognition Disorders/complications/*pathology
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted/methods
MH  - *Magnetic Resonance Imaging/classification/methods
MH  - Male
MH  - Nerve Net/blood supply/pathology/physiopathology
MH  - Neuropsychological Tests
MH  - Oxygen/blood
MH  - *Visual Cortex/blood supply/pathology/physiopathology
MH  - *Visual Pathways/blood supply/pathology/physiopathology
MH  - Visual Perception/physiology
EDAT- 2010/09/18 06:00
MHDA- 2011/03/10 06:00
CRDT- 2010/09/18 06:00
PHST- 2010/09/18 06:00 [entrez]
PHST- 2010/09/18 06:00 [pubmed]
PHST- 2011/03/10 06:00 [medline]
AID - 33Q1363472758283 [pii]
AID - 10.3233/JAD-2010-101038 [doi]
PST - ppublish
SO  - J Alzheimers Dis. 2010;22(2):523-39. doi: 10.3233/JAD-2010-101038.