PMID- 20849355
OWN - NLM
STAT- MEDLINE
DCOM- 20110111
LR  - 20161125
IS  - 1091-7691 (Electronic)
IS  - 0895-8378 (Linking)
VI  - 22
IP  - 12
DP  - 2010 Oct
TI  - Airborne Asian sand dust enhances murine lung eosinophilia.
PG  - 1012-25
LID - 10.3109/08958378.2010.510151 [doi]
AB  - There is no experimental study demonstrating the effects of airborne Asian sand 
      dust (AASD) on allergic lung eosinophilia. The organic substances adsorbed onto 
      AASD collected from the atmosphere of Iki-island in Japan were excluded by heat 
      treatment at 360 degrees C for 30 min. The effects of AASD or heated-AASD (H-AASD) 
      towards allergic lung inflammation were compared in murine lungs to investigate 
      the role of organic substances. ICR mice were administrated with the two kinds of 
      AASD and/or ovalbumin (OVA) intratracheally four times at 2-week intervals. AASD 
      and H-AASD enhanced eosinophil recruitment induced by OVA in the alveoli and in 
      the submucosa of the airway, which has a goblet cell proliferation in the 
      bronchial epithelium. AASD and H-AASD synergistically increased Th2 
      cytokines-interleukin-13 (IL-13), eosinophil-relevant cytokine and chemokine, 
      such as IL-5, and monocyte chemotactic protein-3 (MCP-3) induced by OVA in whole 
      lung lavage fluid. The enhancing effects were much greater in AASD than in 
      H-AASD. AASD induced adjuvant effects on OVA-specific immunoglobulin E (IgE) and 
      IgG1 production. In an in vitro study using RAW264.7 cells, AASD increased the 
      expression of Toll-like receptors 2 (TLR2) mRNA, but not TLR4 mRNA. AASD 
      increased mRNA expression of NALP3, ASC, and IL-1ss compared with the control. 
      H-AASD caused no expression of either mRNA. These results suggest that the 
      aggravated lung eosinophilia in AASD is due to activation of a Th2-associated 
      immune response and that the activation of TLR2 and NALP3 inflammasome by 
      microbial materials could be participating in this phenomenon.
FAU - He, Miao
AU  - He M
AD  - Department of Environmental and Occupational Health, College of Public Health, 
      China Medical University, Shenyang, China.
FAU - Ichinose, Takamichi
AU  - Ichinose T
FAU - Yoshida, Seiichi
AU  - Yoshida S
FAU - Nishikawa, Masataka
AU  - Nishikawa M
FAU - Mori, Ikuko
AU  - Mori I
FAU - Yanagisawa, Rie
AU  - Yanagisawa R
FAU - Takano, Hirohisa
AU  - Takano H
FAU - Inoue, Ken-ichiro
AU  - Inoue K
FAU - Sun, Guifan
AU  - Sun G
FAU - Shibamoto, Takayuki
AU  - Shibamoto T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Inhal Toxicol
JT  - Inhalation toxicology
JID - 8910739
RN  - 0 (Air Pollutants)
RN  - 0 (Carrier Proteins)
RN  - 0 (Cytokines)
RN  - 0 (Dust)
RN  - 0 (Immunoglobulins)
RN  - 0 (NLR Family, Pyrin Domain-Containing 3 Protein)
RN  - 0 (Nlrp3 protein, mouse)
RN  - 0 (Particulate Matter)
RN  - 0 (Tlr2 protein, mouse)
RN  - 0 (Toll-Like Receptor 2)
RN  - 7631-86-9 (Silicon Dioxide)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Air Pollutants/immunology/*toxicity
MH  - *Air Pollution
MH  - Animals
MH  - Carrier Proteins/genetics/metabolism
MH  - Cell Line
MH  - Cytokines/metabolism
MH  - Drug Synergism
MH  - Dust/immunology
MH  - Eosinophils/*drug effects/immunology/pathology
MH  - Gene Expression/drug effects
MH  - Immunoglobulins/metabolism
MH  - Inhalation Exposure
MH  - Macrophages/drug effects/immunology/pathology
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - NLR Family, Pyrin Domain-Containing 3 Protein
MH  - Ovalbumin/immunology
MH  - Particulate Matter
MH  - Pulmonary Alveoli/drug effects/immunology/pathology
MH  - Pulmonary Eosinophilia/*chemically induced/immunology/pathology
MH  - Silicon Dioxide/immunology/*toxicity
MH  - Toll-Like Receptor 2/genetics/metabolism
EDAT- 2010/09/21 06:00
MHDA- 2011/01/12 06:00
CRDT- 2010/09/21 06:00
PHST- 2010/09/21 06:00 [entrez]
PHST- 2010/09/21 06:00 [pubmed]
PHST- 2011/01/12 06:00 [medline]
AID - 10.3109/08958378.2010.510151 [doi]
PST - ppublish
SO  - Inhal Toxicol. 2010 Oct;22(12):1012-25. doi: 10.3109/08958378.2010.510151.