PMID- 20849479
OWN - NLM
STAT- MEDLINE
DCOM- 20110208
LR  - 20161125
IS  - 1540-8175 (Electronic)
IS  - 0742-2822 (Linking)
VI  - 27
IP  - 8
DP  - 2010 Sep
TI  - Echocardiographic study of a Mestizo-Mexican population with Marfan syndrome.
PG  - 923-30
LID - 10.1111/j.1540-8175.2010.01208.x [doi]
AB  - BACKGROUND: The cardiovascular manifestations of Marfan syndrome (MFS) are the 
      main causes of morbidity and mortality. This study describes the clinical and 
      echocardiographic findings in a Mestizo-Mexican population affected by the 
      disease. METHODS: A total of 166 patients previously diagnosed with MFS were 
      recruited for the study, 114 of them underwent complete clinical history, with 
      emphasis on Ghent nosology criteria, and transthoracic echocardiography, with 68 
      patients also undergoing transesophageal study. RESULTS: Major cardiovascular 
      criteria from the Ghent nosology predominated in adults (P < 0.0001), minor 
      criteria in children (P = 0.007). Among pediatric patients, 83% had a New York 
      Heart Association (NYHA) functional class of I; however, 64% of the adult 
      patients had an NYHA class >/=II, (P < 0.0001). Corrected aortic echocardiographic 
      measurements of both groups demonstrated statistically significant differences. 
      Children had a greater prevalence of mitral valve prolapse, while adults more 
      frequently presented with aortic complications. Seven patients died during 
      follow-up from aortic complications, one child and six adults. CONCLUSIONS: Based 
      on the data, we can conclude that MFS in the Mestizo-Mexican population has a 
      distinctly different clinical pattern in children and adults, and a graver 
      prognosis in adults. Adult patients with MFS are significantly more likely, than 
      children, to have aortic dilation, aortic aneurysm, aortic regurgitation, 
      aneurysm rupture, aortic dissection, and fatal outcome. Children with MFS are 
      more likely, than adults, to present with asymptomatic mitral and tricuspid 
      prolapse and mitral valve regurgitation.
CI  - (c) 2010, Wiley Periodicals, Inc.
FAU - Espinola-Zavaleta, Nilda
AU  - Espinola-Zavaleta N
AD  - Immunology Department, Instituto Nacional de Cardiologia Ignacio Chavez, Juan 
      Badiano No. 1, Mexico City, Mexico.
FAU - Iqbal, Fahad M
AU  - Iqbal FM
FAU - Nanda, Navin C
AU  - Nanda NC
FAU - Enriquez-Rodriguez, Eduardo
AU  - Enriquez-Rodriguez E
FAU - Amezcua-Guerra, Luis M
AU  - Amezcua-Guerra LM
FAU - Bojalil-Parra, Rafael
AU  - Bojalil-Parra R
FAU - Reyes, Pedro A
AU  - Reyes PA
FAU - Soto, Maria Elena
AU  - Soto ME
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Echocardiography
JT  - Echocardiography (Mount Kisco, N.Y.)
JID - 8511187
SB  - IM
MH  - Adult
MH  - Child
MH  - Female
MH  - Humans
MH  - Male
MH  - Marfan Syndrome/*diagnostic imaging/*epidemiology
MH  - Mexico/epidemiology
MH  - Prevalence
MH  - Ultrasonography/*statistics & numerical data
EDAT- 2010/09/21 06:00
MHDA- 2011/02/09 06:00
CRDT- 2010/09/21 06:00
PHST- 2010/09/21 06:00 [entrez]
PHST- 2010/09/21 06:00 [pubmed]
PHST- 2011/02/09 06:00 [medline]
AID - 10.1111/j.1540-8175.2010.01208.x [doi]
PST - ppublish
SO  - Echocardiography. 2010 Sep;27(8):923-30. doi: 10.1111/j.1540-8175.2010.01208.x.