PMID- 20849871
OWN - NLM
STAT- MEDLINE
DCOM- 20110215
LR  - 20101124
IS  - 1873-2518 (Electronic)
IS  - 0264-410X (Linking)
VI  - 28
IP  - 50
DP  - 2010 Nov 23
TI  - Molecular mechanisms for plasmacytoid dendritic cell function and development.
PG  - 8046-7
LID - 10.1016/j.vaccine.2010.09.025 [doi]
AB  - Dendritic cells (DCs) are activated by immune adjuvants in a DC subset-specific 
      manner. Plasmacytoid DC (pDC) is a unique subset that senses nucleic acid immune 
      adjuvants only through two Toll-like receptors (TLRs), TLR7 and TLR9 and produces 
      large amounts of type I interferons. Here I review recent trend in pDC function 
      and development.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Kaisho, Tsuneyasu
AU  - Kaisho T
AD  - Laboratory for Host Defense, RIKEN Research Center for Allergy and Immunology, 
      Suehiro-cho 1-7-22, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan. 
      tkaisho@rcai.riken.jp
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100917
PL  - Netherlands
TA  - Vaccine
JT  - Vaccine
JID - 8406899
RN  - 0 (Adjuvants, Immunologic)
RN  - 0 (Interferon Type I)
RN  - 0 (Nucleic Acids)
RN  - 0 (Toll-Like Receptor 7)
RN  - 0 (Toll-Like Receptor 9)
SB  - IM
MH  - Adjuvants, Immunologic/genetics
MH  - Animals
MH  - Dendritic Cells/*immunology/physiology
MH  - Interferon Type I/immunology
MH  - Mice
MH  - Nucleic Acids/immunology
MH  - Signal Transduction
MH  - Toll-Like Receptor 7/*immunology
MH  - Toll-Like Receptor 9/*immunology
EDAT- 2010/09/21 06:00
MHDA- 2011/02/16 06:00
CRDT- 2010/09/21 06:00
PHST- 2010/02/23 00:00 [received]
PHST- 2010/04/15 00:00 [accepted]
PHST- 2010/09/21 06:00 [entrez]
PHST- 2010/09/21 06:00 [pubmed]
PHST- 2011/02/16 06:00 [medline]
AID - S0264-410X(10)01335-6 [pii]
AID - 10.1016/j.vaccine.2010.09.025 [doi]
PST - ppublish
SO  - Vaccine. 2010 Nov 23;28(50):8046-7. doi: 10.1016/j.vaccine.2010.09.025. Epub 2010 
      Sep 17.