PMID- 20849917
OWN - NLM
STAT- MEDLINE
DCOM- 20110128
LR  - 20211020
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 485
IP  - 3
DP  - 2010 Nov 26
TI  - Effects of intra-hippocampal injections of the NK2 receptor antagonist saredutant 
      on the elevated plus maze, and the mouse defense test battery.
PG  - 241-5
LID - 10.1016/j.neulet.2010.09.021 [doi]
AB  - Intracerebroventricular (i.c.v.) or intraperitoneal (IP) administration of 
      saredutant (SR48968), an NK2 receptor antagonist, produces anxiolytic-like 
      effects in rodents in a number of animal models of anxiety. NK2 binding sites are 
      present in several limbic structures in rats, including the hippocampus, 
      thalamus, septum and prefrontal cortex, suggesting involvement in the modulation 
      of emotional processes. The current study investigated the behavioral effects of 
      saredutant infused into the ventral hippocampus (VH), a structure associated with 
      cognitive and emotional processes, to clarify the neural substrate underlying the 
      anxiolytic-like effect of the compound. Saredutant (10, 100 or 500 pmol/0.2 muL) 
      was injected bilaterally into the VH of male CD-1 mice tested in the elevated 
      plus-maze and mouse defense test battery (MDTB). Results from the EPM showed that 
      microinjections of 10 pmol/0.2 muL of saredutant increased entries and time spent 
      in the open arms and enhanced end-arm exploration. In the MDTB, saredutant (500 
      pmol/0.2 muL) decreased vocalizations and increased escape attempts in mice 
      confronted with a rat. Taken together, these results suggest that hippocampal 
      tachykinin mechanisms are involved in the modulation of anxiety and defensive 
      behaviors.
CI  - Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Borelli, Karina Genaro
AU  - Borelli KG
AD  - Nucleo de Cognicao e Sistemas Complexos, Centro de Matematica, Computacao e 
      Cognicao, Universidade Federal do ABC, 09090-400 Santo Andre, SP, Brazil. 
      karina.borelli@ufabc.edu.br
FAU - Defensor, Erwin B
AU  - Defensor EB
FAU - Blanchard, D Caroline
AU  - Blanchard DC
FAU - Blanchard, Robert J
AU  - Blanchard RJ
FAU - Griebel, Guy
AU  - Griebel G
LA  - eng
GR  - R01 MH081845/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100919
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Anti-Anxiety Agents)
RN  - 0 (Benzamides)
RN  - 0 (Piperidines)
RN  - 0 (Receptors, Neurokinin-2)
RN  - 720U2QK8I5 (SR 48968)
SB  - IM
MH  - Animals
MH  - Anti-Anxiety Agents/administration & dosage/*pharmacology
MH  - Anxiety/*psychology
MH  - Avoidance Learning/drug effects
MH  - Benzamides/administration & dosage/*pharmacology
MH  - Cats
MH  - Escape Reaction/drug effects
MH  - Exploratory Behavior/drug effects
MH  - Hippocampus/anatomy & histology/*physiology
MH  - Male
MH  - Mice
MH  - Microinjections
MH  - Odorants
MH  - Piperidines/administration & dosage/*pharmacology
MH  - Rats
MH  - Rats, Long-Evans
MH  - Receptors, Neurokinin-2/*antagonists & inhibitors
MH  - Stereotaxic Techniques
EDAT- 2010/09/21 06:00
MHDA- 2011/02/01 06:00
CRDT- 2010/09/21 06:00
PHST- 2010/07/18 00:00 [received]
PHST- 2010/08/30 00:00 [revised]
PHST- 2010/09/05 00:00 [accepted]
PHST- 2010/09/21 06:00 [entrez]
PHST- 2010/09/21 06:00 [pubmed]
PHST- 2011/02/01 06:00 [medline]
AID - S0304-3940(10)01212-7 [pii]
AID - 10.1016/j.neulet.2010.09.021 [doi]
PST - ppublish
SO  - Neurosci Lett. 2010 Nov 26;485(3):241-5. doi: 10.1016/j.neulet.2010.09.021. Epub 
      2010 Sep 19.