PMID- 20850122
OWN - NLM
STAT- MEDLINE
DCOM- 20101230
LR  - 20131121
IS  - 1873-3778 (Electronic)
IS  - 0021-9673 (Linking)
VI  - 1217
IP  - 42
DP  - 2010 Oct 15
TI  - Analysis of thyroid hormones in raw and treated waste water.
PG  - 6469-74
LID - 10.1016/j.chroma.2010.08.032 [doi]
AB  - An analytical method for the quantification of thyroid hormones 
      (3,5,3',5'-tetraiodo-L-thyronine, 3,3',5-triiodo-L-thyronine, 
      3,3',5'-triiodothyronine, 3,5-diiodothyronine, 3,3'-diiodothyronine) in different 
      water matrices has been developed. The method, consisting of solid phase 
      extraction (SPE) and liquid chromatography-tandem mass spectrometry (LC-MS/MS), 
      was validated for tap and surface water as well as raw and treated waste water. 
      The limits of quantifications (LOQs) were lowest in tap water, where they ranged 
      from 1.1 to 13.3 ng L(-1), and highest in raw wastewater (10.5-84.9 ng L(-1)). Of 
      the target analytes 3,5,3',5'-tetraiodo-L-thyronine (T(4)) could be quantified in 
      the influent and effluent of a waste water treatment plant (WWTP) in Finland. The 
      study showed that despite a relatively high removal rate during treatment (66%), 
      part of the incoming T(4) will reach the aquatic environment and, due to the high 
      endocrine activity of this compound, further studies are needed in order to 
      assess its environmental fate and impact on natural ecosystems.
CI  - Copyright (c) 2010 Elsevier B.V. All rights reserved.
FAU - Svanfelt, Jesper
AU  - Svanfelt J
AD  - Abo Akademi University, Laboratory of Organic Chemistry, Biskopsgatan 8, 
      FIN-20500 Turku, Finland.
FAU - Eriksson, Johan
AU  - Eriksson J
FAU - Kronberg, Leif
AU  - Kronberg L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100819
PL  - Netherlands
TA  - J Chromatogr A
JT  - Journal of chromatography. A
JID - 9318488
RN  - 0 (Sewage)
RN  - 0 (Water Pollutants, Chemical)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Sewage/chemistry
MH  - Solid Phase Extraction/*methods
MH  - Tandem Mass Spectrometry/*methods
MH  - Thyroxine/*analysis/chemistry
MH  - Water Pollutants, Chemical/*analysis/chemistry
MH  - Water Purification
MH  - Water Supply/analysis
EDAT- 2010/09/21 06:00
MHDA- 2010/12/31 06:00
CRDT- 2010/09/21 06:00
PHST- 2010/05/18 00:00 [received]
PHST- 2010/07/23 00:00 [revised]
PHST- 2010/08/11 00:00 [accepted]
PHST- 2010/09/21 06:00 [entrez]
PHST- 2010/09/21 06:00 [pubmed]
PHST- 2010/12/31 06:00 [medline]
AID - S0021-9673(10)01103-9 [pii]
AID - 10.1016/j.chroma.2010.08.032 [doi]
PST - ppublish
SO  - J Chromatogr A. 2010 Oct 15;1217(42):6469-74. doi: 10.1016/j.chroma.2010.08.032. 
      Epub 2010 Aug 19.