PMID- 20851016
OWN - NLM
STAT- MEDLINE
DCOM- 20110310
LR  - 20211203
IS  - 1878-3511 (Electronic)
IS  - 1201-9712 (Linking)
VI  - 14
IP  - 11
DP  - 2010 Nov
TI  - Absence of consistent association between human leukocyte antigen-I and -II 
      alleles and human T-lymphotropic virus type 1 (HTLV-1)-associated 
      myelopathy/tropical spastic paraparesis risk in an HTLV-1 French Afro-Caribbean 
      population.
PG  - e986-90
LID - 10.1016/j.ijid.2010.05.020 [doi]
AB  - OBJECTIVES: Human T-cell lymphotropic virus type 1 (HTLV-1) infection leads to 
      the risk of developing HTLV-1-associated myelopathy/tropical spastic paraparesis 
      (HAM/TSP) in less than 5% of cases. The mechanism of disease progression in 
      HAM/TSP remains unknown. A significant role of certain human leukocyte antigen 
      (HLA) genotypes in determining the risk of HAM/TSP has been reported in Japan, 
      where the HLA-A*02 gene has been found to be associated with a lower HTLV-1 
      provirus load and with protection from HAM/TSP, whereas HLA-DRB1*0101 has been 
      found to be associated with an increased susceptibility to HAM/TSP. The aim of 
      the present case-control study was to investigate the HLA class I and class II 
      allele distribution in HTLV-seropositive French Afro-Caribbean individuals, 
      originating from the French West Indies. METHODS: Associations with HLA class I 
      (A and B) and class II (DRB1 and DQB1) alleles were tested in 123 HAM/TSP 
      patients and 85 asymptomatic HTLV-1 carriers. HLA typing was undertaken on 
      genomic DNA extracted from peripheral blood leukocytes. RESULTS: In our cohort, 
      no significant effect on either the risk of developing HAM/TSP or HTLV-1 provirus 
      load was found for HLA class I or class II, including HLA-A*02 (p=0.43). 
      CONCLUSIONS: Our findings are in contrast to those in the Japanese population, 
      however the literature on HLA associations in HTLV-1 infections across different 
      populations over the past decade have reported conflicting results and this 
      suggests strong ethnic disparities.
CI  - Copyright (c) 2010 International Society for Infectious Diseases. Published by 
      Elsevier Ltd. All rights reserved.
FAU - Deschamps, Romain
AU  - Deschamps R
AD  - Centre de Reference Caribeen des Maladies Rares Neurologiques et 
      Neuro-musculaires, Centre Hospitalier Universitaire Pierre Zobda-Quitman, 97200 
      Fort de France, Martinique. romain.deschamps@chu-fortdefrance.fr
FAU - Bera, Odile
AU  - Bera O
FAU - Belrose, Gilda
AU  - Belrose G
FAU - Lezin, Agnes
AU  - Lezin A
FAU - Bellance, Remi
AU  - Bellance R
FAU - Signate, Aissatou
AU  - Signate A
FAU - Cabre, Philippe
AU  - Cabre P
FAU - Smadja, Didier
AU  - Smadja D
FAU - Cesaire, Raymond
AU  - Cesaire R
FAU - Olindo, Stephane
AU  - Olindo S
LA  - eng
PT  - Journal Article
DEP - 20100917
PL  - Canada
TA  - Int J Infect Dis
JT  - International journal of infectious diseases : IJID : official publication of the 
      International Society for Infectious Diseases
JID - 9610933
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - *Alleles
MH  - Case-Control Studies
MH  - Ethnicity/genetics
MH  - Female
MH  - Follow-Up Studies
MH  - Genetic Predisposition to Disease
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Histocompatibility Antigens Class II/*genetics
MH  - Human T-lymphotropic virus 1/immunology
MH  - Humans
MH  - Male
MH  - Martinique
MH  - Middle Aged
MH  - Paraparesis, Tropical Spastic/complications/ethnology/*genetics
MH  - Proviruses/genetics/immunology
MH  - Risk Factors
MH  - Viral Load
EDAT- 2010/09/21 06:00
MHDA- 2011/03/11 06:00
CRDT- 2010/09/21 06:00
PHST- 2010/02/05 00:00 [received]
PHST- 2010/05/18 00:00 [revised]
PHST- 2010/05/28 00:00 [accepted]
PHST- 2010/09/21 06:00 [entrez]
PHST- 2010/09/21 06:00 [pubmed]
PHST- 2011/03/11 06:00 [medline]
AID - S1201-9712(10)02443-4 [pii]
AID - 10.1016/j.ijid.2010.05.020 [doi]
PST - ppublish
SO  - Int J Infect Dis. 2010 Nov;14(11):e986-90. doi: 10.1016/j.ijid.2010.05.020. Epub 
      2010 Sep 17.